Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytop...

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Autores principales:	Yoonmi Lee, Nam Hee Kim, Eunae Sandra Cho, Ji Hye Yang, Yong Hoon Cha, Hee Eun Kang, Jun Seop Yun, Sue Bean Cho, Seon-Hyeong Lee, Petra Paclikova, Tomasz W. Radaszkiewicz, Vitezslav Bryja, Chi Gu Kang, Young Soo Yuk, So Young Cha, Soo-Youl Kim, Hyun Sil Kim, Jong In Yook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5664ab6c4abb4c098757cecb0a32f56a
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spelling	oai:doaj.org-article:5664ab6c4abb4c098757cecb0a32f56a2021-12-02T17:33:19ZDishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner10.1038/s41467-018-04757-w2041-1723https://doaj.org/article/5664ab6c4abb4c098757cecb0a32f56a2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04757-whttps://doaj.org/toc/2041-1723Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytoplasm and nucleus in specific tumor suppressor contexts.Yoonmi LeeNam Hee KimEunae Sandra ChoJi Hye YangYong Hoon ChaHee Eun KangJun Seop YunSue Bean ChoSeon-Hyeong LeePetra PaclikovaTomasz W. RadaszkiewiczVitezslav BryjaChi Gu KangYoung Soo YukSo Young ChaSoo-Youl KimHyun Sil KimJong In YookNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoonmi Lee Nam Hee Kim Eunae Sandra Cho Ji Hye Yang Yong Hoon Cha Hee Eun Kang Jun Seop Yun Sue Bean Cho Seon-Hyeong Lee Petra Paclikova Tomasz W. Radaszkiewicz Vitezslav Bryja Chi Gu Kang Young Soo Yuk So Young Cha Soo-Youl Kim Hyun Sil Kim Jong In Yook Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
description	Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytoplasm and nucleus in specific tumor suppressor contexts.
format	article
author	Yoonmi Lee Nam Hee Kim Eunae Sandra Cho Ji Hye Yang Yong Hoon Cha Hee Eun Kang Jun Seop Yun Sue Bean Cho Seon-Hyeong Lee Petra Paclikova Tomasz W. Radaszkiewicz Vitezslav Bryja Chi Gu Kang Young Soo Yuk So Young Cha Soo-Youl Kim Hyun Sil Kim Jong In Yook
author_facet	Yoonmi Lee Nam Hee Kim Eunae Sandra Cho Ji Hye Yang Yong Hoon Cha Hee Eun Kang Jun Seop Yun Sue Bean Cho Seon-Hyeong Lee Petra Paclikova Tomasz W. Radaszkiewicz Vitezslav Bryja Chi Gu Kang Young Soo Yuk So Young Cha Soo-Youl Kim Hyun Sil Kim Jong In Yook
author_sort	Yoonmi Lee
title	Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
title_short	Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
title_full	Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
title_fullStr	Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
title_full_unstemmed	Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
title_sort	dishevelled has a yap nuclear export function in a tumor suppressor context-dependent manner
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5664ab6c4abb4c098757cecb0a32f56a
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Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

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