Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles

To address the shortcomings in the application of bioactive peptides as drugs, incorporation of unnatural amino acids (UAAs) has been used. Here, the authors report an ionic compound-promoted C-N cleavage of alkyl pyridinium to generate alkyl radicals upon excitation by visible light, and apply it f...

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Autores principales:	Mengran Wang, Chao Wang, Yumei Huo, Xiaobo Dang, Hongxiang Xue, Liangyu Liu, Hongli Chai, Xiuling Xie, Zhixuan Li, Doudou Lu, Zhaoqing Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5665235ea1bb4639a2d037b49ae0f71f
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spelling	oai:doaj.org-article:5665235ea1bb4639a2d037b49ae0f71f2021-11-28T12:33:55ZVisible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles10.1038/s41467-021-27086-x2041-1723https://doaj.org/article/5665235ea1bb4639a2d037b49ae0f71f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27086-xhttps://doaj.org/toc/2041-1723To address the shortcomings in the application of bioactive peptides as drugs, incorporation of unnatural amino acids (UAAs) has been used. Here, the authors report an ionic compound-promoted C-N cleavage of alkyl pyridinium to generate alkyl radicals upon excitation by visible light, and apply it for deaminative hydroalkylation of alkenes to synthesise diverse β-alkyl substituted UAAs.Mengran WangChao WangYumei HuoXiaobo DangHongxiang XueLiangyu LiuHongli ChaiXiuling XieZhixuan LiDoudou LuZhaoqing XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengran Wang Chao Wang Yumei Huo Xiaobo Dang Hongxiang Xue Liangyu Liu Hongli Chai Xiuling Xie Zhixuan Li Doudou Lu Zhaoqing Xu Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
description	To address the shortcomings in the application of bioactive peptides as drugs, incorporation of unnatural amino acids (UAAs) has been used. Here, the authors report an ionic compound-promoted C-N cleavage of alkyl pyridinium to generate alkyl radicals upon excitation by visible light, and apply it for deaminative hydroalkylation of alkenes to synthesise diverse β-alkyl substituted UAAs.
format	article
author	Mengran Wang Chao Wang Yumei Huo Xiaobo Dang Hongxiang Xue Liangyu Liu Hongli Chai Xiuling Xie Zhixuan Li Doudou Lu Zhaoqing Xu
author_facet	Mengran Wang Chao Wang Yumei Huo Xiaobo Dang Hongxiang Xue Liangyu Liu Hongli Chai Xiuling Xie Zhixuan Li Doudou Lu Zhaoqing Xu
author_sort	Mengran Wang
title	Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
title_short	Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
title_full	Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
title_fullStr	Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
title_full_unstemmed	Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
title_sort	visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5665235ea1bb4639a2d037b49ae0f71f
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Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles

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