Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

How tumor cells control metastatic niche formation is not fully understood. Here, the authors show in a lung metastatic niche, high-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that leads to activation of β1-integrin-NF-κBsignalling, converting fibroblasts to cancer-associa...

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Autores principales:	Tian Fang, Hongwei Lv, Guishuai Lv, Ting Li, Changzheng Wang, Qin Han, Lexing Yu, Bo Su, Linna Guo, Shanna Huang, Dan Cao, Liang Tang, Shanhua Tang, Mengchao Wu, Wen Yang, Hongyang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56663e7b53fa4b999a5fcecf5c866460
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:56663e7b53fa4b999a5fcecf5c8664602021-12-02T16:56:57ZTumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer10.1038/s41467-017-02583-02041-1723https://doaj.org/article/56663e7b53fa4b999a5fcecf5c8664602018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02583-0https://doaj.org/toc/2041-1723How tumor cells control metastatic niche formation is not fully understood. Here, the authors show in a lung metastatic niche, high-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that leads to activation of β1-integrin-NF-κBsignalling, converting fibroblasts to cancer-associated fibroblasts.Tian FangHongwei LvGuishuai LvTing LiChangzheng WangQin HanLexing YuBo SuLinna GuoShanna HuangDan CaoLiang TangShanhua TangMengchao WuWen YangHongyang WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tian Fang Hongwei Lv Guishuai Lv Ting Li Changzheng Wang Qin Han Lexing Yu Bo Su Linna Guo Shanna Huang Dan Cao Liang Tang Shanhua Tang Mengchao Wu Wen Yang Hongyang Wang Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
description	How tumor cells control metastatic niche formation is not fully understood. Here, the authors show in a lung metastatic niche, high-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that leads to activation of β1-integrin-NF-κBsignalling, converting fibroblasts to cancer-associated fibroblasts.
format	article
author	Tian Fang Hongwei Lv Guishuai Lv Ting Li Changzheng Wang Qin Han Lexing Yu Bo Su Linna Guo Shanna Huang Dan Cao Liang Tang Shanhua Tang Mengchao Wu Wen Yang Hongyang Wang
author_facet	Tian Fang Hongwei Lv Guishuai Lv Ting Li Changzheng Wang Qin Han Lexing Yu Bo Su Linna Guo Shanna Huang Dan Cao Liang Tang Shanhua Tang Mengchao Wu Wen Yang Hongyang Wang
author_sort	Tian Fang
title	Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
title_short	Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
title_full	Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
title_fullStr	Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
title_full_unstemmed	Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
title_sort	tumor-derived exosomal mir-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/56663e7b53fa4b999a5fcecf5c866460
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Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

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