Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study

Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study

Linghui Dian,1,2,* Zhiwen Yang,3,* Feng Li,1 Zhouhua Wang,1 Xin Pan,1 Xinsheng Peng,2 Xintian Huang,1 Zhefei Guo,1 Guilan Quan,1 Xuan Shi,1 Bao Chen,1 Ge Li,4 Chuanbin Wu1,41School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People’s Republic of Chin...

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Autores principales: Dian L, Yang Z, Li F, Wang Z, Pan X, Peng X, Huang X, Guo Z, Quan G, Shi X, Chen B, Li G, Wu C
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/566bc2b734724ddd885e372e779afc75
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spelling oai:doaj.org-article:566bc2b734724ddd885e372e779afc752021-12-02T02:10:34ZCubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study1176-91141178-2013https://doaj.org/article/566bc2b734724ddd885e372e779afc752013-02-01T00:00:00Zhttp://www.dovepress.com/cubic-phase-nanoparticles-for-sustained-release-of-ibuprofen-formulati-a12305https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Linghui Dian,1,2,* Zhiwen Yang,3,* Feng Li,1 Zhouhua Wang,1 Xin Pan,1 Xinsheng Peng,2 Xintian Huang,1 Zhefei Guo,1 Guilan Quan,1 Xuan Shi,1 Bao Chen,1 Ge Li,4 Chuanbin Wu1,41School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People’s Republic of China; 2School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, People’s Republic of China; 3Department of Gastroenterology, Songjiang Branch of the Affiliated First People’s Hospital of Shanghai Jiaotong University, Shanghai, People’s Republic of China; 4Guangdong Research Center for Drug Delivery Systems, Guangzhou, People’s Republic of China*These authors contributed equally to this workAbstract: In order to improve the oral bioavailability of ibuprofen, ibuprofen-loaded cubic nanoparticles were prepared as a delivery system for aqueous formulations. The cubic inner structure was verified by cryogenic transmission electron microscopy. With an encapsulation efficiency greater than 85%, the ibuprofen-loaded cubic nanoparticles had a narrow size distribution around a mean size of 238 nm. Differential scanning calorimetry and X-ray diffraction determined that ibuprofen was in an amorphous and molecular form within the lipid matrix. The in vitro release of ibuprofen from cubic nanoparticles was greater than 80% at 24 hours, showing sustained characteristics. The pharmacokinetic study in beagle dogs showed improved absorption of ibuprofen from cubic nanoparticles compared to that of pure ibuprofen, with evidence of a longer half-life and a relative oral bioavailability of 222% (P < 0.05). The ibuprofen-loaded cubic nanoparticles provide a promising carrier candidate with an efficient drug delivery for therapeutic treatment.Keywords: ibuprofen, cubic nanoparticles, oral drug delivery, bioavailabilityDian LYang ZLi FWang ZPan XPeng XHuang XGuo ZQuan GShi XChen BLi GWu CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 845-854 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Dian L
Yang Z
Li F
Wang Z
Pan X
Peng X
Huang X
Guo Z
Quan G
Shi X
Chen B
Li G
Wu C
Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
description Linghui Dian,1,2,* Zhiwen Yang,3,* Feng Li,1 Zhouhua Wang,1 Xin Pan,1 Xinsheng Peng,2 Xintian Huang,1 Zhefei Guo,1 Guilan Quan,1 Xuan Shi,1 Bao Chen,1 Ge Li,4 Chuanbin Wu1,41School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People’s Republic of China; 2School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, People’s Republic of China; 3Department of Gastroenterology, Songjiang Branch of the Affiliated First People’s Hospital of Shanghai Jiaotong University, Shanghai, People’s Republic of China; 4Guangdong Research Center for Drug Delivery Systems, Guangzhou, People’s Republic of China*These authors contributed equally to this workAbstract: In order to improve the oral bioavailability of ibuprofen, ibuprofen-loaded cubic nanoparticles were prepared as a delivery system for aqueous formulations. The cubic inner structure was verified by cryogenic transmission electron microscopy. With an encapsulation efficiency greater than 85%, the ibuprofen-loaded cubic nanoparticles had a narrow size distribution around a mean size of 238 nm. Differential scanning calorimetry and X-ray diffraction determined that ibuprofen was in an amorphous and molecular form within the lipid matrix. The in vitro release of ibuprofen from cubic nanoparticles was greater than 80% at 24 hours, showing sustained characteristics. The pharmacokinetic study in beagle dogs showed improved absorption of ibuprofen from cubic nanoparticles compared to that of pure ibuprofen, with evidence of a longer half-life and a relative oral bioavailability of 222% (P < 0.05). The ibuprofen-loaded cubic nanoparticles provide a promising carrier candidate with an efficient drug delivery for therapeutic treatment.Keywords: ibuprofen, cubic nanoparticles, oral drug delivery, bioavailability
format article
author Dian L
Yang Z
Li F
Wang Z
Pan X
Peng X
Huang X
Guo Z
Quan G
Shi X
Chen B
Li G
Wu C
author_facet Dian L
Yang Z
Li F
Wang Z
Pan X
Peng X
Huang X
Guo Z
Quan G
Shi X
Chen B
Li G
Wu C
author_sort Dian L
title Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
title_short Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
title_full Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
title_fullStr Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
title_full_unstemmed Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
title_sort cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/566bc2b734724ddd885e372e779afc75
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