Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019

Background: Hospital bed saturation has been one of the problems to solve during the SARS-CoV-2 pandemic. However, not every patient who is admitted requires close monitoring or specific therapeutics. Mild cases could be managed in the outpatient setting. Objective: Our study aimed to analyze the ac...

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Autores principales:	Santiago N. Piombi-Adanza, María C. Baretto, Flavia A. Echaide, Josefina Arias-Mahiques, Matías Carreras, Eliana Hidalgo-Fredez, Luciana M. Vignolo, Noel Parodi, Tomás Domínguez- Monclá, Jimena del V. Carlos, María F. Padula, Santiago Haedo, Mariana Sigman, Laura Hermida, María J. Padilla, Francisco Paulin
Formato:	article
Lenguaje:	EN
Publicado:	Permanyer 2021
Materias:	COVID-19. Mild. Pneumonia. SARS-CoV-2. Respiratory failure. Prognosis. Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/566c82ffa3424887969a9edba16fe806
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spelling	oai:doaj.org-article:566c82ffa3424887969a9edba16fe8062021-11-09T14:25:10ZAnalysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 201910.24875/RIC.210001200034-83762564-8896https://doaj.org/article/566c82ffa3424887969a9edba16fe8062021-01-01T00:00:00Zhttps://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=386https://doaj.org/toc/0034-8376https://doaj.org/toc/2564-8896Background: Hospital bed saturation has been one of the problems to solve during the SARS-CoV-2 pandemic. However, not every patient who is admitted requires close monitoring or specific therapeutics. Mild cases could be managed in the outpatient setting. Objective: Our study aimed to analyze the accuracy of the oxygen saturation/respiratory rate (sat/RR) index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment (qSOFA) scores to predict supplemental oxygen requirement and prolonged hospital stay in patients with mild coronavirus disease 2019 (COVID-19). Methods: A prospective cohort study in an academic medical center. We compared the values of these scores according to the occurrence or not of each outcome. When differences between groups were statistically significant, the discriminatory capacity of the score for that outcome was analyzed. Results: We included 271 patients. Of them, 11.07% required supplemental oxygen, showing significantly higher values of NEWS2 score and qSOFA score, and lower values of Sat/RR index. About 38% presented prolonged hospital stay, with significantly higher values of NEWS2 score and lower values of sat/RR index. The ROC curve area under the curve (AUC) of sat/RR index to discriminate the requirement of supplemental oxygen was 0.72 (CI 95% 0.61-0.84). The ROC curve of NEWS2 and qSOFA for the same outcome was 0.75 (95% [95% CI 0.65-0.85]) and 0.66 (95% CI 0.57-0.76), respectively. The ability of the Sat/RR index to discriminate the requirement of prolonged hospitalization showed an AUC of 0.67 (95% [95% CI 0.60-0.73]). The NEWS2 score showed an AUC of 0.63 (CI 95% 0.56-0.70) for the same outcome. Conclusions: sat/RR index and NEWS2 score have a good capacity to discriminate patients at risk of clinical worsening, being the Sat/RR index simpler and easier to calculate. Santiago N. Piombi-AdanzaMaría C. BarettoFlavia A. EchaideJosefina Arias-MahiquesMatías CarrerasEliana Hidalgo-FredezLuciana M. VignoloNoel ParodiTomás Domínguez- MoncláJimena del V. CarlosMaría F. PadulaSantiago HaedoMariana SigmanLaura HermidaMaría J. PadillaFrancisco PaulinPermanyerarticleCOVID-19. Mild. Pneumonia. SARS-CoV-2. Respiratory failure. Prognosis.Internal medicineRC31-1245ENRevista de Investigación Clínica, Vol 73, Iss 6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19. Mild. Pneumonia. SARS-CoV-2. Respiratory failure. Prognosis. Internal medicine RC31-1245
spellingShingle	COVID-19. Mild. Pneumonia. SARS-CoV-2. Respiratory failure. Prognosis. Internal medicine RC31-1245 Santiago N. Piombi-Adanza María C. Baretto Flavia A. Echaide Josefina Arias-Mahiques Matías Carreras Eliana Hidalgo-Fredez Luciana M. Vignolo Noel Parodi Tomás Domínguez- Monclá Jimena del V. Carlos María F. Padula Santiago Haedo Mariana Sigman Laura Hermida María J. Padilla Francisco Paulin Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019
description	Background: Hospital bed saturation has been one of the problems to solve during the SARS-CoV-2 pandemic. However, not every patient who is admitted requires close monitoring or specific therapeutics. Mild cases could be managed in the outpatient setting. Objective: Our study aimed to analyze the accuracy of the oxygen saturation/respiratory rate (sat/RR) index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment (qSOFA) scores to predict supplemental oxygen requirement and prolonged hospital stay in patients with mild coronavirus disease 2019 (COVID-19). Methods: A prospective cohort study in an academic medical center. We compared the values of these scores according to the occurrence or not of each outcome. When differences between groups were statistically significant, the discriminatory capacity of the score for that outcome was analyzed. Results: We included 271 patients. Of them, 11.07% required supplemental oxygen, showing significantly higher values of NEWS2 score and qSOFA score, and lower values of Sat/RR index. About 38% presented prolonged hospital stay, with significantly higher values of NEWS2 score and lower values of sat/RR index. The ROC curve area under the curve (AUC) of sat/RR index to discriminate the requirement of supplemental oxygen was 0.72 (CI 95% 0.61-0.84). The ROC curve of NEWS2 and qSOFA for the same outcome was 0.75 (95% [95% CI 0.65-0.85]) and 0.66 (95% CI 0.57-0.76), respectively. The ability of the Sat/RR index to discriminate the requirement of prolonged hospitalization showed an AUC of 0.67 (95% [95% CI 0.60-0.73]). The NEWS2 score showed an AUC of 0.63 (CI 95% 0.56-0.70) for the same outcome. Conclusions: sat/RR index and NEWS2 score have a good capacity to discriminate patients at risk of clinical worsening, being the Sat/RR index simpler and easier to calculate.
format	article
author	Santiago N. Piombi-Adanza María C. Baretto Flavia A. Echaide Josefina Arias-Mahiques Matías Carreras Eliana Hidalgo-Fredez Luciana M. Vignolo Noel Parodi Tomás Domínguez- Monclá Jimena del V. Carlos María F. Padula Santiago Haedo Mariana Sigman Laura Hermida María J. Padilla Francisco Paulin
author_facet	Santiago N. Piombi-Adanza María C. Baretto Flavia A. Echaide Josefina Arias-Mahiques Matías Carreras Eliana Hidalgo-Fredez Luciana M. Vignolo Noel Parodi Tomás Domínguez- Monclá Jimena del V. Carlos María F. Padula Santiago Haedo Mariana Sigman Laura Hermida María J. Padilla Francisco Paulin
author_sort	Santiago N. Piombi-Adanza
title	Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019
title_short	Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019
title_full	Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019
title_fullStr	Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019
title_full_unstemmed	Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019
title_sort	analysis of oxygen blood saturation/ respiratory rate index, news2, curb65, and quick sequential organ failure assessment scores to assess prognosis in patients with mild coronavirus disease 2019
publisher	Permanyer
publishDate	2021
url	https://doaj.org/article/566c82ffa3424887969a9edba16fe806
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Analysis of Oxygen Blood Saturation/ Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019

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