The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature

Staphylococcus aureus pathogenicity islands (SaPIs) encode the master repressor Stl and after bacteriophage infection Stl interacts with specific phage proteins leading to a derepression of SaPIs. Here the authors provide structural insights into this family of repressors by determining the crystal...

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Autores principales:	J. Rafael Ciges-Tomas, Christian Alite, Suzanne Humphrey, J. Donderis, Janine Bowring, Xavier Salvatella, José R. Penadés, Alberto Marina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/566f46134dd3427ca48ea42f87620741
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spelling	oai:doaj.org-article:566f46134dd3427ca48ea42f876207412021-12-02T15:35:05ZThe structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature10.1038/s41467-019-11504-22041-1723https://doaj.org/article/566f46134dd3427ca48ea42f876207412019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11504-2https://doaj.org/toc/2041-1723Staphylococcus aureus pathogenicity islands (SaPIs) encode the master repressor Stl and after bacteriophage infection Stl interacts with specific phage proteins leading to a derepression of SaPIs. Here the authors provide structural insights into this family of repressors by determining the crystal structures of SaPIbov1 Stl alone and in complex with two structurally unrelated phage dUTPases.J. Rafael Ciges-TomasChristian AliteSuzanne HumphreyJ. DonderisJanine BowringXavier SalvatellaJosé R. PenadésAlberto MarinaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Rafael Ciges-Tomas Christian Alite Suzanne Humphrey J. Donderis Janine Bowring Xavier Salvatella José R. Penadés Alberto Marina The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
description	Staphylococcus aureus pathogenicity islands (SaPIs) encode the master repressor Stl and after bacteriophage infection Stl interacts with specific phage proteins leading to a derepression of SaPIs. Here the authors provide structural insights into this family of repressors by determining the crystal structures of SaPIbov1 Stl alone and in complex with two structurally unrelated phage dUTPases.
format	article
author	J. Rafael Ciges-Tomas Christian Alite Suzanne Humphrey J. Donderis Janine Bowring Xavier Salvatella José R. Penadés Alberto Marina
author_facet	J. Rafael Ciges-Tomas Christian Alite Suzanne Humphrey J. Donderis Janine Bowring Xavier Salvatella José R. Penadés Alberto Marina
author_sort	J. Rafael Ciges-Tomas
title	The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
title_short	The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
title_full	The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
title_fullStr	The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
title_full_unstemmed	The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
title_sort	structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/566f46134dd3427ca48ea42f87620741
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The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature

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