Genetic determinants of cellular addiction to DNA polymerase theta

Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.

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Autores principales:	Wanjuan Feng, Dennis A. Simpson, Juan Carvajal-Garcia, Brandon A. Price, Rashmi J. Kumar, Lisle E. Mose, Richard D. Wood, Naim Rashid, Jeremy E. Purvis, Joel S. Parker, Dale A. Ramsden, Gaorav P. Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/566f9084f7004b948bfb7d7d81816fbb
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spelling	oai:doaj.org-article:566f9084f7004b948bfb7d7d81816fbb2021-12-02T17:02:01ZGenetic determinants of cellular addiction to DNA polymerase theta10.1038/s41467-019-12234-12041-1723https://doaj.org/article/566f9084f7004b948bfb7d7d81816fbb2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12234-1https://doaj.org/toc/2041-1723Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.Wanjuan FengDennis A. SimpsonJuan Carvajal-GarciaBrandon A. PriceRashmi J. KumarLisle E. MoseRichard D. WoodNaim RashidJeremy E. PurvisJoel S. ParkerDale A. RamsdenGaorav P. GuptaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wanjuan Feng Dennis A. Simpson Juan Carvajal-Garcia Brandon A. Price Rashmi J. Kumar Lisle E. Mose Richard D. Wood Naim Rashid Jeremy E. Purvis Joel S. Parker Dale A. Ramsden Gaorav P. Gupta Genetic determinants of cellular addiction to DNA polymerase theta
description	Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.
format	article
author	Wanjuan Feng Dennis A. Simpson Juan Carvajal-Garcia Brandon A. Price Rashmi J. Kumar Lisle E. Mose Richard D. Wood Naim Rashid Jeremy E. Purvis Joel S. Parker Dale A. Ramsden Gaorav P. Gupta
author_facet	Wanjuan Feng Dennis A. Simpson Juan Carvajal-Garcia Brandon A. Price Rashmi J. Kumar Lisle E. Mose Richard D. Wood Naim Rashid Jeremy E. Purvis Joel S. Parker Dale A. Ramsden Gaorav P. Gupta
author_sort	Wanjuan Feng
title	Genetic determinants of cellular addiction to DNA polymerase theta
title_short	Genetic determinants of cellular addiction to DNA polymerase theta
title_full	Genetic determinants of cellular addiction to DNA polymerase theta
title_fullStr	Genetic determinants of cellular addiction to DNA polymerase theta
title_full_unstemmed	Genetic determinants of cellular addiction to DNA polymerase theta
title_sort	genetic determinants of cellular addiction to dna polymerase theta
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/566f9084f7004b948bfb7d7d81816fbb
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Genetic determinants of cellular addiction to DNA polymerase theta

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