Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage

Abstract We studied the mechanisms of anemia and the influence of anemia on renal pathology in Dahl/Salt Sensitive (Dahl/SS) rat, a model of cardio-renal-anemia syndrome. Erythrocyte lifespan was shortened and associated with decreased hemoglobin level in the Dahl/SS rats given high-salt diet. Serum...

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Autores principales:	Eri Manabe, Satoyasu Ito, Yoshiya Ohno, Toshiyuki Tanaka, Yoshiro Naito, Naoko Sasaki, Masanori Asakura, Tohru Masuyama, Masaharu Ishihara, Takeshi Tsujino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56700e5c20e7418aac974b3ec81a2151
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spelling	oai:doaj.org-article:56700e5c20e7418aac974b3ec81a21512021-12-02T13:34:10ZReduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage10.1038/s41598-020-79146-92045-2322https://doaj.org/article/56700e5c20e7418aac974b3ec81a21512020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79146-9https://doaj.org/toc/2045-2322Abstract We studied the mechanisms of anemia and the influence of anemia on renal pathology in Dahl/Salt Sensitive (Dahl/SS) rat, a model of cardio-renal-anemia syndrome. Erythrocyte lifespan was shortened and associated with decreased hemoglobin level in the Dahl/SS rats given high-salt diet. Serum haptoglobin decreased, reticulocytes increased, and erythropoiesis in the bone marrow and extramedullary hematopoiesis in the spleen was markedly stimulated by increased serum erythropoietin in them. As a mechanism of hemolysis, we investigated the incidence of eryptosis, suicidal death of erythrocytes. Eryptosis was increased, and red blood cell-derived microparticles, small particle which are generated in hemolytic disease, were also increased in Dahl/SS rats fed with high-salt diet. Deposition of hemosiderin and mitochondrial morphologic abnormality, a sign of ferroptosis, in proximal renal tubules was associated with intravascular hemolysis. Treatment with deferasirox, an oral iron chelator, reduced the renal proximal tubular injury and the glomerular sclerosis in Dahl/SS rats fed with high-salt diet. In conclusion, reduced half-life of erythrocytes induced by hemolysis is the major cause of anemia in Dahl/SS rat. Iron accumulation induced by hemolysis causes renal proximal tubule injury and accelerates renal damage in this model.Eri ManabeSatoyasu ItoYoshiya OhnoToshiyuki TanakaYoshiro NaitoNaoko SasakiMasanori AsakuraTohru MasuyamaMasaharu IshiharaTakeshi TsujinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eri Manabe Satoyasu Ito Yoshiya Ohno Toshiyuki Tanaka Yoshiro Naito Naoko Sasaki Masanori Asakura Tohru Masuyama Masaharu Ishihara Takeshi Tsujino Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
description	Abstract We studied the mechanisms of anemia and the influence of anemia on renal pathology in Dahl/Salt Sensitive (Dahl/SS) rat, a model of cardio-renal-anemia syndrome. Erythrocyte lifespan was shortened and associated with decreased hemoglobin level in the Dahl/SS rats given high-salt diet. Serum haptoglobin decreased, reticulocytes increased, and erythropoiesis in the bone marrow and extramedullary hematopoiesis in the spleen was markedly stimulated by increased serum erythropoietin in them. As a mechanism of hemolysis, we investigated the incidence of eryptosis, suicidal death of erythrocytes. Eryptosis was increased, and red blood cell-derived microparticles, small particle which are generated in hemolytic disease, were also increased in Dahl/SS rats fed with high-salt diet. Deposition of hemosiderin and mitochondrial morphologic abnormality, a sign of ferroptosis, in proximal renal tubules was associated with intravascular hemolysis. Treatment with deferasirox, an oral iron chelator, reduced the renal proximal tubular injury and the glomerular sclerosis in Dahl/SS rats fed with high-salt diet. In conclusion, reduced half-life of erythrocytes induced by hemolysis is the major cause of anemia in Dahl/SS rat. Iron accumulation induced by hemolysis causes renal proximal tubule injury and accelerates renal damage in this model.
format	article
author	Eri Manabe Satoyasu Ito Yoshiya Ohno Toshiyuki Tanaka Yoshiro Naito Naoko Sasaki Masanori Asakura Tohru Masuyama Masaharu Ishihara Takeshi Tsujino
author_facet	Eri Manabe Satoyasu Ito Yoshiya Ohno Toshiyuki Tanaka Yoshiro Naito Naoko Sasaki Masanori Asakura Tohru Masuyama Masaharu Ishihara Takeshi Tsujino
author_sort	Eri Manabe
title	Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
title_short	Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
title_full	Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
title_fullStr	Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
title_full_unstemmed	Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
title_sort	reduced lifespan of erythrocytes in dahl/salt sensitive rats is the cause of the renal proximal tubule damage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/56700e5c20e7418aac974b3ec81a2151
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Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage

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