Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis

Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis

The most frequent cause of familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are hexanucleotide repeat expansions in the non-coding region of the C9ORF72 gene that are translated into five dipeptide repeat (DPR) proteins. Here, the authors show that proline/arginine (PR)...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Maria Babu, Filippo Favretto, Alain Ibáñez de Opakua, Marija Rankovic, Stefan Becker, Markus Zweckstetter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5671eab95f98401cbdffa726c9e3c6c6
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares