Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al. show that two murine-derived monoclonal antibodies with therapeutic efficacy neutralize virions via binding to the canyon region, creating steric h...

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Autores principales:	Chao Zhang, Cong Xu, Wenlong Dai, Yifan Wang, Zhi Liu, Xueyang Zhang, Xuesong Wang, Haikun Wang, Sitang Gong, Yao Cong, Zhong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5675dadc248d4ebbb892c894b41bba5f
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spelling	oai:doaj.org-article:5675dadc248d4ebbb892c894b41bba5f2021-12-02T15:52:52ZFunctional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections10.1038/s41467-021-23199-52041-1723https://doaj.org/article/5675dadc248d4ebbb892c894b41bba5f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23199-5https://doaj.org/toc/2041-1723Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al. show that two murine-derived monoclonal antibodies with therapeutic efficacy neutralize virions via binding to the canyon region, creating steric hindrance for sialic acid receptor binding.Chao ZhangCong XuWenlong DaiYifan WangZhi LiuXueyang ZhangXuesong WangHaikun WangSitang GongYao CongZhong HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Zhang Cong Xu Wenlong Dai Yifan Wang Zhi Liu Xueyang Zhang Xuesong Wang Haikun Wang Sitang Gong Yao Cong Zhong Huang Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
description	Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al. show that two murine-derived monoclonal antibodies with therapeutic efficacy neutralize virions via binding to the canyon region, creating steric hindrance for sialic acid receptor binding.
format	article
author	Chao Zhang Cong Xu Wenlong Dai Yifan Wang Zhi Liu Xueyang Zhang Xuesong Wang Haikun Wang Sitang Gong Yao Cong Zhong Huang
author_facet	Chao Zhang Cong Xu Wenlong Dai Yifan Wang Zhi Liu Xueyang Zhang Xuesong Wang Haikun Wang Sitang Gong Yao Cong Zhong Huang
author_sort	Chao Zhang
title	Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
title_short	Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
title_full	Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
title_fullStr	Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
title_full_unstemmed	Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections
title_sort	functional and structural characterization of a two-mab cocktail for delayed treatment of enterovirus d68 infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5675dadc248d4ebbb892c894b41bba5f
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Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

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