Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment

Background/Aims. Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur. Our aim was to establish the effectiveness of these drugs in routine clinical practice, as well as to determine factors that cou...

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Autores principales:	María E. Cárdaba-García, Encarnación Abad-Lecha, Miguel Á. Calleja-Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	hepatitis c virus chronic hepatitis c sustained virologic response antiviral agents predictive factors of response Medicine R
Acceso en línea:	https://doaj.org/article/567b00e2f2454fe7991c0b0189658c22
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spelling	oai:doaj.org-article:567b00e2f2454fe7991c0b0189658c222021-11-26T11:19:48ZEffectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment1993-28201819-635710.1080/19932820.2021.1949797https://doaj.org/article/567b00e2f2454fe7991c0b0189658c222021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19932820.2021.1949797https://doaj.org/toc/1993-2820https://doaj.org/toc/1819-6357Background/Aims. Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur. Our aim was to establish the effectiveness of these drugs in routine clinical practice, as well as to determine factors that could influence the response to the treatment.Matherials/methods. Single-center, observational, retrospective study. Clinical, virological and pharmacotherapeutic variables were registered at baseline. Adverse drug reactions that occurred were recorded until week 24 of follow-up. Achievement of sustained virologic response was also recorded. Univariate and multivariate analysis were done to determine factors of response.Results. A total of 333 treatment regimens corresponding to 330 different patients were evaluated. Sustained virologic response rate was 94.6% [95%CI: 91.6–96.6%]. 67.9% of the patients experienced adverse drugs reactions (92.2% were grade 1). The univariate analysis identified a higher baseline of platelets, albumin and total cholesterol as predictive factors of sustained virologic response (p < 0.05). Presence of diabetes and complications related to liver disease (splenomegaly, portal hypertension, portal hypertensive gastropathy), body mass index ≥30, greater liver fibrosis, receiving simeprevir and higher baseline levels of glucose, aspartate-aminotransferase, alanine-aminotransferase and alkaline-phosphatase, have been identified as predictive factors of non-response (p < 0.05). The multivariate analysis detected the following independent factors of non-response: body mass index ≥30 and presence of complications related to liver disease.Conclusion. The effectiveness and safety of direct-acting antivirals against hepatitis C virus have been maintained in routine clinical practice. Further research on predictive factors of response is required in order to develop more reliable and reproducible predictive models.María E. Cárdaba-GarcíaEncarnación Abad-LechaMiguel Á. Calleja-HernándezTaylor & Francis Grouparticlehepatitis c viruschronic hepatitis csustained virologic responseantiviral agentspredictive factors of responseMedicineRENLibyan Journal of Medicine, Vol 16, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis c virus chronic hepatitis c sustained virologic response antiviral agents predictive factors of response Medicine R
spellingShingle	hepatitis c virus chronic hepatitis c sustained virologic response antiviral agents predictive factors of response Medicine R María E. Cárdaba-García Encarnación Abad-Lecha Miguel Á. Calleja-Hernández Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment
description	Background/Aims. Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur. Our aim was to establish the effectiveness of these drugs in routine clinical practice, as well as to determine factors that could influence the response to the treatment.Matherials/methods. Single-center, observational, retrospective study. Clinical, virological and pharmacotherapeutic variables were registered at baseline. Adverse drug reactions that occurred were recorded until week 24 of follow-up. Achievement of sustained virologic response was also recorded. Univariate and multivariate analysis were done to determine factors of response.Results. A total of 333 treatment regimens corresponding to 330 different patients were evaluated. Sustained virologic response rate was 94.6% [95%CI: 91.6–96.6%]. 67.9% of the patients experienced adverse drugs reactions (92.2% were grade 1). The univariate analysis identified a higher baseline of platelets, albumin and total cholesterol as predictive factors of sustained virologic response (p < 0.05). Presence of diabetes and complications related to liver disease (splenomegaly, portal hypertension, portal hypertensive gastropathy), body mass index ≥30, greater liver fibrosis, receiving simeprevir and higher baseline levels of glucose, aspartate-aminotransferase, alanine-aminotransferase and alkaline-phosphatase, have been identified as predictive factors of non-response (p < 0.05). The multivariate analysis detected the following independent factors of non-response: body mass index ≥30 and presence of complications related to liver disease.Conclusion. The effectiveness and safety of direct-acting antivirals against hepatitis C virus have been maintained in routine clinical practice. Further research on predictive factors of response is required in order to develop more reliable and reproducible predictive models.
format	article
author	María E. Cárdaba-García Encarnación Abad-Lecha Miguel Á. Calleja-Hernández
author_facet	María E. Cárdaba-García Encarnación Abad-Lecha Miguel Á. Calleja-Hernández
author_sort	María E. Cárdaba-García
title	Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment
title_short	Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment
title_full	Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment
title_fullStr	Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment
title_full_unstemmed	Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment
title_sort	effectiveness of direct-acting antiviral drugs against hepatitis c virus: predictive factors of response to the treatment
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/567b00e2f2454fe7991c0b0189658c22
work_keys_str_mv	AT mariaecardabagarcia effectivenessofdirectactingantiviraldrugsagainsthepatitiscviruspredictivefactorsofresponsetothetreatment AT encarnacionabadlecha effectivenessofdirectactingantiviraldrugsagainsthepatitiscviruspredictivefactorsofresponsetothetreatment AT miguelacallejahernandez effectivenessofdirectactingantiviraldrugsagainsthepatitiscviruspredictivefactorsofresponsetothetreatment
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Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment

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