Gut microbiota alterations in response to sleep length among African-origin adults.
Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5682431fbe4642638db4d1f8e25fad75 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5682431fbe4642638db4d1f8e25fad75 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5682431fbe4642638db4d1f8e25fad752021-12-02T20:04:42ZGut microbiota alterations in response to sleep length among African-origin adults.1932-620310.1371/journal.pone.0255323https://doaj.org/article/5682431fbe4642638db4d1f8e25fad752021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255323https://doaj.org/toc/1932-6203Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In this study, we investigated the impact of sleep length on the gut microbiota in a large cohort of 655 participants of African descent, aged 25-45, from Ghana, South Africa (SA), Jamaica, and the United States (US). The sleep duration was self-reported via a questionnaire. Participants were classified into 3 sleep groups: short (<7hrs), normal (7-<9hrs), and long (≥9hrs). Forty-seven percent of US participants were classified as short sleepers and 88% of SA participants as long sleepers. Gut microbial composition analysis (16S rRNA gene sequencing) revealed that bacterial alpha diversity negatively correlated with sleep length (p<0.05). Furthermore, sleep length significantly contributed to the inter-individual beta diversity dissimilarity in gut microbial composition (p<0.01). Participants with both short and long-sleep durations exhibited significantly higher abundances of several taxonomic features, compared to normal sleep duration participants. The predicted relative proportion of two genes involved in the butyrate synthesis via lysine pathway were enriched in short sleep duration participants. Finally, co-occurrence relationships revealed by network analysis showed unique interactions among the short, normal and long duration sleepers. These results suggest that sleep length in humans may alter gut microbiota by driving population shifts of the whole microbiota and also specific changes in Exact Sequence Variants abundance, which may have implications for chronic inflammation associated diseases. The current findings suggest a possible relationship between disrupted sleep patterns and the composition of the gut microbiota. Prospective investigations in larger and more prolonged sleep researches and causally experimental studies are needed to confirm these findings, investigate the underlying mechanism and determine whether improving microbial homeostasis may buffer against sleep-related health decline in humans.Na FeiCandice Choo-KangSirimon ReutrakulStephanie J CrowleyDale RaeKweku Bedu-AddoJacob Plange-RhuleTerrence E ForresterEstelle V LambertPascal BovetWalter RiesenWolfgang KorteAmy LukeBrian T LaydenJack A GilbertLara R DugasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255323 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Na Fei Candice Choo-Kang Sirimon Reutrakul Stephanie J Crowley Dale Rae Kweku Bedu-Addo Jacob Plange-Rhule Terrence E Forrester Estelle V Lambert Pascal Bovet Walter Riesen Wolfgang Korte Amy Luke Brian T Layden Jack A Gilbert Lara R Dugas Gut microbiota alterations in response to sleep length among African-origin adults. |
| description |
Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In this study, we investigated the impact of sleep length on the gut microbiota in a large cohort of 655 participants of African descent, aged 25-45, from Ghana, South Africa (SA), Jamaica, and the United States (US). The sleep duration was self-reported via a questionnaire. Participants were classified into 3 sleep groups: short (<7hrs), normal (7-<9hrs), and long (≥9hrs). Forty-seven percent of US participants were classified as short sleepers and 88% of SA participants as long sleepers. Gut microbial composition analysis (16S rRNA gene sequencing) revealed that bacterial alpha diversity negatively correlated with sleep length (p<0.05). Furthermore, sleep length significantly contributed to the inter-individual beta diversity dissimilarity in gut microbial composition (p<0.01). Participants with both short and long-sleep durations exhibited significantly higher abundances of several taxonomic features, compared to normal sleep duration participants. The predicted relative proportion of two genes involved in the butyrate synthesis via lysine pathway were enriched in short sleep duration participants. Finally, co-occurrence relationships revealed by network analysis showed unique interactions among the short, normal and long duration sleepers. These results suggest that sleep length in humans may alter gut microbiota by driving population shifts of the whole microbiota and also specific changes in Exact Sequence Variants abundance, which may have implications for chronic inflammation associated diseases. The current findings suggest a possible relationship between disrupted sleep patterns and the composition of the gut microbiota. Prospective investigations in larger and more prolonged sleep researches and causally experimental studies are needed to confirm these findings, investigate the underlying mechanism and determine whether improving microbial homeostasis may buffer against sleep-related health decline in humans. |
| format |
article |
| author |
Na Fei Candice Choo-Kang Sirimon Reutrakul Stephanie J Crowley Dale Rae Kweku Bedu-Addo Jacob Plange-Rhule Terrence E Forrester Estelle V Lambert Pascal Bovet Walter Riesen Wolfgang Korte Amy Luke Brian T Layden Jack A Gilbert Lara R Dugas |
| author_facet |
Na Fei Candice Choo-Kang Sirimon Reutrakul Stephanie J Crowley Dale Rae Kweku Bedu-Addo Jacob Plange-Rhule Terrence E Forrester Estelle V Lambert Pascal Bovet Walter Riesen Wolfgang Korte Amy Luke Brian T Layden Jack A Gilbert Lara R Dugas |
| author_sort |
Na Fei |
| title |
Gut microbiota alterations in response to sleep length among African-origin adults. |
| title_short |
Gut microbiota alterations in response to sleep length among African-origin adults. |
| title_full |
Gut microbiota alterations in response to sleep length among African-origin adults. |
| title_fullStr |
Gut microbiota alterations in response to sleep length among African-origin adults. |
| title_full_unstemmed |
Gut microbiota alterations in response to sleep length among African-origin adults. |
| title_sort |
gut microbiota alterations in response to sleep length among african-origin adults. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/5682431fbe4642638db4d1f8e25fad75 |
| work_keys_str_mv |
AT nafei gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT candicechookang gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT sirimonreutrakul gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT stephaniejcrowley gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT dalerae gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT kwekubeduaddo gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT jacobplangerhule gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT terrenceeforrester gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT estellevlambert gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT pascalbovet gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT walterriesen gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT wolfgangkorte gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT amyluke gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT briantlayden gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT jackagilbert gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults AT larardugas gutmicrobiotaalterationsinresponsetosleeplengthamongafricanoriginadults |
| _version_ |
1718375542112124928 |