Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma

Kenji Inoue,1 Minako Shiokawa,1 Takayuki Fujimoto,1 Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and...

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Autores principales:	Inoue K, Shiokawa M, Fujimoto T, Tomita G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5682c1a30e894256b839485753691b7e
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spelling	oai:doaj.org-article:5682c1a30e894256b839485753691b7e2021-12-02T09:07:32ZEffects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma1177-5483https://doaj.org/article/5682c1a30e894256b839485753691b7e2014-06-01T00:00:00Zhttp://www.dovepress.com/effects-of-treatment-with-bimatoprost-003-for-3-years-in-patients-with-a17278https://doaj.org/toc/1177-5483 Kenji Inoue,1 Minako Shiokawa,1 Takayuki Fujimoto,1 Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance.Methods: We monitored the IOP of 62 patients with normal-tension glaucoma every 1–3 months. The Humphrey visual field test was performed every 6 months after treatment and the results obtained were compared to those before treatment. In addition, visual field performance was evaluated using trend and event analysis.Results: The mean ± standard deviation (SD) of IOP after treatment with bimatoprost for 3 years (13.6±3.1 mmHg) was significantly lower than that before treatment (16.8±2.4 mmHg, P<0.0001). No change was observed in the mean deviation and pattern SD values of the Humphrey visual field before and 3 years after treatment. Worsening of visual field performance was observed in one patient (3.0%) by using trend analysis and in four patients (12.1%) by using event analysis. Treatment was discontinued in 17 patients (27.4%) because of adverse reactions.Conclusion: Bimatoprost 0.03% single treatment was effective in reducing the IOP at least during the 3 years of treatment, but visual field performance worsened by 3.0%–12.1% in patients with normal-tension glaucoma.Keywords: IOP, visual field, trend analysis, event analysisInoue KShiokawa MFujimoto TTomita GDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1179-1183 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Inoue K Shiokawa M Fujimoto T Tomita G Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
description	Kenji Inoue,1 Minako Shiokawa,1 Takayuki Fujimoto,1 Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance.Methods: We monitored the IOP of 62 patients with normal-tension glaucoma every 1–3 months. The Humphrey visual field test was performed every 6 months after treatment and the results obtained were compared to those before treatment. In addition, visual field performance was evaluated using trend and event analysis.Results: The mean ± standard deviation (SD) of IOP after treatment with bimatoprost for 3 years (13.6±3.1 mmHg) was significantly lower than that before treatment (16.8±2.4 mmHg, P<0.0001). No change was observed in the mean deviation and pattern SD values of the Humphrey visual field before and 3 years after treatment. Worsening of visual field performance was observed in one patient (3.0%) by using trend analysis and in four patients (12.1%) by using event analysis. Treatment was discontinued in 17 patients (27.4%) because of adverse reactions.Conclusion: Bimatoprost 0.03% single treatment was effective in reducing the IOP at least during the 3 years of treatment, but visual field performance worsened by 3.0%–12.1% in patients with normal-tension glaucoma.Keywords: IOP, visual field, trend analysis, event analysis
format	article
author	Inoue K Shiokawa M Fujimoto T Tomita G
author_facet	Inoue K Shiokawa M Fujimoto T Tomita G
author_sort	Inoue K
title	Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
title_short	Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
title_full	Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
title_fullStr	Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
title_full_unstemmed	Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
title_sort	effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/5682c1a30e894256b839485753691b7e
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Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma

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