Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging

Unnikrishnan Nair,1,2 Jay U Sheth,1,2 Asmita Indurkar,1 Manoj Soman1,2 1Vitreoretinal Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India; 2Department of Research, Chaithanya Innovation in Technology and Eyecare (Research), Trivandrum, Kerala, IndiaCorrespondence: Jay...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nair U, Sheth JU, Indurkar A, Soman M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	macular hole spectral-domain optical coherence tomography en face imaging intraretinal cysts Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5687ea49c7844280a7ecb18561abae8e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5687ea49c7844280a7ecb18561abae8e
record_format	dspace
spelling	oai:doaj.org-article:5687ea49c7844280a7ecb18561abae8e2021-12-02T18:31:00ZIntraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging1177-5483https://doaj.org/article/5687ea49c7844280a7ecb18561abae8e2021-07-01T00:00:00Zhttps://www.dovepress.com/intraretinal-cysts-in-macular-hole-a-structure-function-correlation-ba-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Unnikrishnan Nair,1,2 Jay U Sheth,1,2 Asmita Indurkar,1 Manoj Soman1,2 1Vitreoretinal Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India; 2Department of Research, Chaithanya Innovation in Technology and Eyecare (Research), Trivandrum, Kerala, IndiaCorrespondence: Jay U Sheth 32, Shiv-Mahal, Mathuradas Road, Kandivali (West), Mumbai, 400067, Maharashtra, IndiaTel +91 9961167200Email drjay009@gmail.comPurpose: To characterize retinal micromorphic changes on en face optical coherence tomography (OCT) and to determine their role in pathogenesis and visual outcomes in macular hole (MH) surgery.Patients and Methods: This is a retrospective, interventional, consecutive case series of 28 eyes undergoing successful MH surgery. Pre- and post-operative en face OCT were manually segmented, and the correlation between parameters such as MH basal diameter and minimal inlet area, area of cyst in inner plexiform layer (IPL) and outer plexiform layer (OPL), percentage of cyst in IPL and OPL, and amount of ellipsoid zone (EZ) defect and external limiting membrane (ELM) defect was performed. Their relationship with visual acuity (VA) outcomes (Group 1: ≥ 20/60; 14 eyes; Group 2: < 20/60; 14 eyes) was also evaluated.Results: A significant positive correlation was noted between the cyst area in OPL and IPL (r=0.768; p< 0.001), which in turn were positively correlated with the basal diameter of the MH in all eyes. The cyst area was significantly more in IPL as compared to OPL in all eyes (p=0.049) and in group 2 (p=0.03) but not in group 1 (p=0.62). As compared to group 2, eyes in group 1 had significantly better pre- and post-operative VA, and significantly smaller basal diameter, minimal inlet area, area of cyst in IPL and OPL, and amount of defect in the ELM (postoperative) and EZ (pre- and post-operative), respectively.Conclusion: An increase in the basal diameter of the MH is associated with a simultaneous congruous enlargement of the area of cyst in IPL and OPL. Based on these imaging findings, we propose that the possible rationale for the origin of these intraretinal cysts could be a breakdown in the physiological retinal pigment epithelium (RPE) pump due to the anatomical separation of the neurosensory retina from the underlying RPE, ie, “RPE contact loss” theory.Keywords: macular hole, spectral-domain optical coherence tomography, en face imaging, intraretinal cystsNair USheth JUIndurkar ASoman MDove Medical Pressarticlemacular holespectral-domain optical coherence tomographyen face imagingintraretinal cystsOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2953-2962 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macular hole spectral-domain optical coherence tomography en face imaging intraretinal cysts Ophthalmology RE1-994
spellingShingle	macular hole spectral-domain optical coherence tomography en face imaging intraretinal cysts Ophthalmology RE1-994 Nair U Sheth JU Indurkar A Soman M Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging
description	Unnikrishnan Nair,1,2 Jay U Sheth,1,2 Asmita Indurkar,1 Manoj Soman1,2 1Vitreoretinal Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India; 2Department of Research, Chaithanya Innovation in Technology and Eyecare (Research), Trivandrum, Kerala, IndiaCorrespondence: Jay U Sheth 32, Shiv-Mahal, Mathuradas Road, Kandivali (West), Mumbai, 400067, Maharashtra, IndiaTel +91 9961167200Email drjay009@gmail.comPurpose: To characterize retinal micromorphic changes on en face optical coherence tomography (OCT) and to determine their role in pathogenesis and visual outcomes in macular hole (MH) surgery.Patients and Methods: This is a retrospective, interventional, consecutive case series of 28 eyes undergoing successful MH surgery. Pre- and post-operative en face OCT were manually segmented, and the correlation between parameters such as MH basal diameter and minimal inlet area, area of cyst in inner plexiform layer (IPL) and outer plexiform layer (OPL), percentage of cyst in IPL and OPL, and amount of ellipsoid zone (EZ) defect and external limiting membrane (ELM) defect was performed. Their relationship with visual acuity (VA) outcomes (Group 1: ≥ 20/60; 14 eyes; Group 2: < 20/60; 14 eyes) was also evaluated.Results: A significant positive correlation was noted between the cyst area in OPL and IPL (r=0.768; p< 0.001), which in turn were positively correlated with the basal diameter of the MH in all eyes. The cyst area was significantly more in IPL as compared to OPL in all eyes (p=0.049) and in group 2 (p=0.03) but not in group 1 (p=0.62). As compared to group 2, eyes in group 1 had significantly better pre- and post-operative VA, and significantly smaller basal diameter, minimal inlet area, area of cyst in IPL and OPL, and amount of defect in the ELM (postoperative) and EZ (pre- and post-operative), respectively.Conclusion: An increase in the basal diameter of the MH is associated with a simultaneous congruous enlargement of the area of cyst in IPL and OPL. Based on these imaging findings, we propose that the possible rationale for the origin of these intraretinal cysts could be a breakdown in the physiological retinal pigment epithelium (RPE) pump due to the anatomical separation of the neurosensory retina from the underlying RPE, ie, “RPE contact loss” theory.Keywords: macular hole, spectral-domain optical coherence tomography, en face imaging, intraretinal cysts
format	article
author	Nair U Sheth JU Indurkar A Soman M
author_facet	Nair U Sheth JU Indurkar A Soman M
author_sort	Nair U
title	Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging
title_short	Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging
title_full	Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging
title_fullStr	Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging
title_full_unstemmed	Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging
title_sort	intraretinal cysts in macular hole: a structure-function correlation based on en face imaging
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5687ea49c7844280a7ecb18561abae8e
work_keys_str_mv	AT nairu intraretinalcystsinmacularholeastructurefunctioncorrelationbasedonenfaceimaging AT shethju intraretinalcystsinmacularholeastructurefunctioncorrelationbasedonenfaceimaging AT indurkara intraretinalcystsinmacularholeastructurefunctioncorrelationbasedonenfaceimaging AT somanm intraretinalcystsinmacularholeastructurefunctioncorrelationbasedonenfaceimaging
_version_	1718377977094340608

Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging

Ejemplares similares