Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation

Travis Cantu,1 Kyle Walsh,2 Varun P Pattani,3 Austin J Moy,3 James W Tunnell,3 Jennifer A Irvin,1,2 Tania Betancourt1,2 1Materials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, TX, USA; 2Department of Chemistry and Biochemistry, Texas State University, San...

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Autores principales:	Cantu T, Walsh K, Pattani VP, Moy AJ, Tunnell JW, Irvin JA, Betancourt T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Conductive polymers nanoparticles ovarian cancer emulsion polymerization nanomedicine photothermal ablation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/568a06a0802e4c9383d3311b6326f18b
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spelling	oai:doaj.org-article:568a06a0802e4c9383d3311b6326f18b2021-12-02T01:32:50ZConductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation1178-2013https://doaj.org/article/568a06a0802e4c9383d3311b6326f18b2017-01-01T00:00:00Zhttps://www.dovepress.com/conductive-polymer-based-nanoparticles-for-laser-mediated-photothermal-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Travis Cantu,1 Kyle Walsh,2 Varun P Pattani,3 Austin J Moy,3 James W Tunnell,3 Jennifer A Irvin,1,2 Tania Betancourt1,2 1Materials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, TX, USA; 2Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA; 3Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA Abstract: Laser-mediated photothermal ablation of cancer cells aided by photothermal agents is a promising strategy for localized, externally controlled cancer treatment. We report the synthesis, characterization, and in vitro evaluation of conductive polymeric nanoparticles (CPNPs) of poly(diethyl-4,4'-{[2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-1,4-phenylene]bis(oxy)}dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid and poly(4-styrenesulfonic acid-co-maleic acid) as photothermal ablation agents. The nanoparticles were prepared by oxidative-emulsion polymerization, yielding stable aqueous suspensions of spherical particles of <100 nm diameter as determined by dynamic light scattering and electron microscopy. Both types of nanoparticles show strong absorption of light in the near infrared region, with absorption peaks at 780 nm for P1 and 750 nm for PEDOT, as well as high photothermal conversion efficiencies (~50%), that is higher than commercially available gold-based photothermal ablation agents. The nanoparticles show significant photostability as determined by their ability to achieve consistent temperatures and to maintain their morphology upon repeated cycles of laser irradiation. In vitro studies in MDA-MB-231 breast cancer cells demonstrate the cytocompatibility of the CPNPs and their ability to mediate complete cancer cell ablation upon irradiation with an 808-nm laser, thereby establishing the potential of these systems as agents for laser-induced photothermal therapy. Keywords: conductive polymers, nanoparticles, breast cancer, emulsion polymerization, nanomedicine, photothermal ablation, PEDOT, photothermal conversion efficiency, MDA-MB-231Cantu TWalsh KPattani VPMoy AJTunnell JWIrvin JABetancourt TDove Medical PressarticleConductive polymersnanoparticlesovarian canceremulsion polymerizationnanomedicinephotothermal ablationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 615-632 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Conductive polymers nanoparticles ovarian cancer emulsion polymerization nanomedicine photothermal ablation Medicine (General) R5-920
spellingShingle	Conductive polymers nanoparticles ovarian cancer emulsion polymerization nanomedicine photothermal ablation Medicine (General) R5-920 Cantu T Walsh K Pattani VP Moy AJ Tunnell JW Irvin JA Betancourt T Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
description	Travis Cantu,1 Kyle Walsh,2 Varun P Pattani,3 Austin J Moy,3 James W Tunnell,3 Jennifer A Irvin,1,2 Tania Betancourt1,2 1Materials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, TX, USA; 2Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA; 3Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA Abstract: Laser-mediated photothermal ablation of cancer cells aided by photothermal agents is a promising strategy for localized, externally controlled cancer treatment. We report the synthesis, characterization, and in vitro evaluation of conductive polymeric nanoparticles (CPNPs) of poly(diethyl-4,4'-{[2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-1,4-phenylene]bis(oxy)}dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid and poly(4-styrenesulfonic acid-co-maleic acid) as photothermal ablation agents. The nanoparticles were prepared by oxidative-emulsion polymerization, yielding stable aqueous suspensions of spherical particles of <100 nm diameter as determined by dynamic light scattering and electron microscopy. Both types of nanoparticles show strong absorption of light in the near infrared region, with absorption peaks at 780 nm for P1 and 750 nm for PEDOT, as well as high photothermal conversion efficiencies (~50%), that is higher than commercially available gold-based photothermal ablation agents. The nanoparticles show significant photostability as determined by their ability to achieve consistent temperatures and to maintain their morphology upon repeated cycles of laser irradiation. In vitro studies in MDA-MB-231 breast cancer cells demonstrate the cytocompatibility of the CPNPs and their ability to mediate complete cancer cell ablation upon irradiation with an 808-nm laser, thereby establishing the potential of these systems as agents for laser-induced photothermal therapy. Keywords: conductive polymers, nanoparticles, breast cancer, emulsion polymerization, nanomedicine, photothermal ablation, PEDOT, photothermal conversion efficiency, MDA-MB-231
format	article
author	Cantu T Walsh K Pattani VP Moy AJ Tunnell JW Irvin JA Betancourt T
author_facet	Cantu T Walsh K Pattani VP Moy AJ Tunnell JW Irvin JA Betancourt T
author_sort	Cantu T
title	Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
title_short	Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
title_full	Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
title_fullStr	Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
title_full_unstemmed	Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
title_sort	conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/568a06a0802e4c9383d3311b6326f18b
work_keys_str_mv	AT cantut conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation AT walshk conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation AT pattanivp conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation AT moyaj conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation AT tunnelljw conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation AT irvinja conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation AT betancourtt conductivepolymerbasednanoparticlesforlasermediatedphotothermalablationofcancersynthesischaracterizationandinvitroevaluation
_version_	1718403014110216192

Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation

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