Interferon lambda protects the female reproductive tract against Zika virus infection

Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent rol...

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Autores principales:	Elizabeth A. Caine, Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, Michael S. Diamond
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/568be70d5e744aafb4350b13e5aaa00d
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spelling	oai:doaj.org-article:568be70d5e744aafb4350b13e5aaa00d2021-12-02T16:58:05ZInterferon lambda protects the female reproductive tract against Zika virus infection10.1038/s41467-018-07993-22041-1723https://doaj.org/article/568be70d5e744aafb4350b13e5aaa00d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07993-2https://doaj.org/toc/2041-1723Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease.Elizabeth A. CaineSuzanne M. ScheafferNitin AroraKonstantin ZaitsevMaxim N. ArtyomovCarolyn B. CoyneKelle H. MoleyMichael S. DiamondNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth A. Caine Suzanne M. Scheaffer Nitin Arora Konstantin Zaitsev Maxim N. Artyomov Carolyn B. Coyne Kelle H. Moley Michael S. Diamond Interferon lambda protects the female reproductive tract against Zika virus infection
description	Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease.
format	article
author	Elizabeth A. Caine Suzanne M. Scheaffer Nitin Arora Konstantin Zaitsev Maxim N. Artyomov Carolyn B. Coyne Kelle H. Moley Michael S. Diamond
author_facet	Elizabeth A. Caine Suzanne M. Scheaffer Nitin Arora Konstantin Zaitsev Maxim N. Artyomov Carolyn B. Coyne Kelle H. Moley Michael S. Diamond
author_sort	Elizabeth A. Caine
title	Interferon lambda protects the female reproductive tract against Zika virus infection
title_short	Interferon lambda protects the female reproductive tract against Zika virus infection
title_full	Interferon lambda protects the female reproductive tract against Zika virus infection
title_fullStr	Interferon lambda protects the female reproductive tract against Zika virus infection
title_full_unstemmed	Interferon lambda protects the female reproductive tract against Zika virus infection
title_sort	interferon lambda protects the female reproductive tract against zika virus infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/568be70d5e744aafb4350b13e5aaa00d
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Interferon lambda protects the female reproductive tract against Zika virus infection

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