Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Lack of respiratory complex I is a hallmark of oncocytomas. Here the authors show that inactivation of this complex via knockout of the NDUFS3 subunit or using metformin, converts tumors from an aggressive phenotype into low-proliferative oncocytomas, which can be further inhibited by targeting pro-...

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Autores principales:	Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli, Giuseppe Gasparre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5695fa0483614fb297fba6aa895d1974
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spelling	oai:doaj.org-article:5695fa0483614fb297fba6aa895d19742021-12-02T17:02:01ZInducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses10.1038/s41467-019-08839-12041-1723https://doaj.org/article/5695fa0483614fb297fba6aa895d19742019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08839-1https://doaj.org/toc/2041-1723Lack of respiratory complex I is a hallmark of oncocytomas. Here the authors show that inactivation of this complex via knockout of the NDUFS3 subunit or using metformin, converts tumors from an aggressive phenotype into low-proliferative oncocytomas, which can be further inhibited by targeting pro-tumorigenic macrophages.Ivana KurelacLuisa IommariniRenaud VatrinetLaura Benedetta AmatoMonica De LuiseGiulia LeoneGiulia GirolimettiNikkitha Umesh GaneshVictoria Louise BridgemanLuigi OmbratoMarta ColumbaroMoira RagazziLara GibelliniManuela SollazzoRene Gunther FeichtingerSilvia VidaliMaurizio BaldassarreSarah ForielMichele VidoneAndrea CossarizzaDaniela GrifoniBarbara KoflerIlaria MalanchiAnna Maria PorcelliGiuseppe GasparreNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivana Kurelac Luisa Iommarini Renaud Vatrinet Laura Benedetta Amato Monica De Luise Giulia Leone Giulia Girolimetti Nikkitha Umesh Ganesh Victoria Louise Bridgeman Luigi Ombrato Marta Columbaro Moira Ragazzi Lara Gibellini Manuela Sollazzo Rene Gunther Feichtinger Silvia Vidali Maurizio Baldassarre Sarah Foriel Michele Vidone Andrea Cossarizza Daniela Grifoni Barbara Kofler Ilaria Malanchi Anna Maria Porcelli Giuseppe Gasparre Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
description	Lack of respiratory complex I is a hallmark of oncocytomas. Here the authors show that inactivation of this complex via knockout of the NDUFS3 subunit or using metformin, converts tumors from an aggressive phenotype into low-proliferative oncocytomas, which can be further inhibited by targeting pro-tumorigenic macrophages.
format	article
author	Ivana Kurelac Luisa Iommarini Renaud Vatrinet Laura Benedetta Amato Monica De Luise Giulia Leone Giulia Girolimetti Nikkitha Umesh Ganesh Victoria Louise Bridgeman Luigi Ombrato Marta Columbaro Moira Ragazzi Lara Gibellini Manuela Sollazzo Rene Gunther Feichtinger Silvia Vidali Maurizio Baldassarre Sarah Foriel Michele Vidone Andrea Cossarizza Daniela Grifoni Barbara Kofler Ilaria Malanchi Anna Maria Porcelli Giuseppe Gasparre
author_facet	Ivana Kurelac Luisa Iommarini Renaud Vatrinet Laura Benedetta Amato Monica De Luise Giulia Leone Giulia Girolimetti Nikkitha Umesh Ganesh Victoria Louise Bridgeman Luigi Ombrato Marta Columbaro Moira Ragazzi Lara Gibellini Manuela Sollazzo Rene Gunther Feichtinger Silvia Vidali Maurizio Baldassarre Sarah Foriel Michele Vidone Andrea Cossarizza Daniela Grifoni Barbara Kofler Ilaria Malanchi Anna Maria Porcelli Giuseppe Gasparre
author_sort	Ivana Kurelac
title	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
title_short	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
title_full	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
title_fullStr	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
title_full_unstemmed	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
title_sort	inducing cancer indolence by targeting mitochondrial complex i is potentiated by blocking macrophage-mediated adaptive responses
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5695fa0483614fb297fba6aa895d1974
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Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

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