Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.

<h4>Background</h4>Although schizophrenia has been associated with abnormalities in brain anatomy, imaging studies have not fully determined the nature and relative contributions of gray matter (GM) and white matter (WM) disturbances underlying these findings. We sought to determine the...

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Autores principales:	Tiziano Colibazzi, Bruce E Wexler, Ravi Bansal, Xuejun Hao, Jun Liu, Juan Sanchez-Peña, Cheryl Corcoran, Jeffrey A Lieberman, Bradley S Peterson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56985a72e3474d56adfa826caaa155b6
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spelling	oai:doaj.org-article:56985a72e3474d56adfa826caaa155b62021-11-18T07:57:49ZAnatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.1932-620310.1371/journal.pone.0055783https://doaj.org/article/56985a72e3474d56adfa826caaa155b62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23418459/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Although schizophrenia has been associated with abnormalities in brain anatomy, imaging studies have not fully determined the nature and relative contributions of gray matter (GM) and white matter (WM) disturbances underlying these findings. We sought to determine the pattern and distribution of these GM and WM abnormalities. Furthermore, we aimed to clarify the contribution of abnormalities in cortical thickness and cortical surface area to the reduced GM volumes reported in schizophrenia.<h4>Methods</h4>We recruited 76 persons with schizophrenia and 57 healthy controls from the community and obtained measures of cortical and WM surface areas, of local volumes along the brain and WM surfaces, and of cortical thickness.<h4>Results</h4>We detected reduced local volumes in patients along corresponding locations of the brain and WM surfaces in addition to bilateral greater thickness of perisylvian cortices and thinner cortex in the superior frontal and cingulate gyri. Total cortical and WM surface areas were reduced. Patients with worse performance on the serial-position task, a measure of working memory, had a higher burden of WM abnormalities.<h4>Conclusions</h4>Reduced local volumes along the surface of the brain mirrored the locations of abnormalities along the surface of the underlying WM, rather than of abnormalities of cortical thickness. Moreover, anatomical features of white matter, but not cortical thickness, correlated with measures of working memory. We propose that reductions in WM and smaller total cortical surface area could be central anatomical abnormalities in schizophrenia, driving, at least partially, the reduced regional GM volumes often observed in this illness.Tiziano ColibazziBruce E WexlerRavi BansalXuejun HaoJun LiuJuan Sanchez-PeñaCheryl CorcoranJeffrey A LiebermanBradley S PetersonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55783 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiziano Colibazzi Bruce E Wexler Ravi Bansal Xuejun Hao Jun Liu Juan Sanchez-Peña Cheryl Corcoran Jeffrey A Lieberman Bradley S Peterson Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
description	<h4>Background</h4>Although schizophrenia has been associated with abnormalities in brain anatomy, imaging studies have not fully determined the nature and relative contributions of gray matter (GM) and white matter (WM) disturbances underlying these findings. We sought to determine the pattern and distribution of these GM and WM abnormalities. Furthermore, we aimed to clarify the contribution of abnormalities in cortical thickness and cortical surface area to the reduced GM volumes reported in schizophrenia.<h4>Methods</h4>We recruited 76 persons with schizophrenia and 57 healthy controls from the community and obtained measures of cortical and WM surface areas, of local volumes along the brain and WM surfaces, and of cortical thickness.<h4>Results</h4>We detected reduced local volumes in patients along corresponding locations of the brain and WM surfaces in addition to bilateral greater thickness of perisylvian cortices and thinner cortex in the superior frontal and cingulate gyri. Total cortical and WM surface areas were reduced. Patients with worse performance on the serial-position task, a measure of working memory, had a higher burden of WM abnormalities.<h4>Conclusions</h4>Reduced local volumes along the surface of the brain mirrored the locations of abnormalities along the surface of the underlying WM, rather than of abnormalities of cortical thickness. Moreover, anatomical features of white matter, but not cortical thickness, correlated with measures of working memory. We propose that reductions in WM and smaller total cortical surface area could be central anatomical abnormalities in schizophrenia, driving, at least partially, the reduced regional GM volumes often observed in this illness.
format	article
author	Tiziano Colibazzi Bruce E Wexler Ravi Bansal Xuejun Hao Jun Liu Juan Sanchez-Peña Cheryl Corcoran Jeffrey A Lieberman Bradley S Peterson
author_facet	Tiziano Colibazzi Bruce E Wexler Ravi Bansal Xuejun Hao Jun Liu Juan Sanchez-Peña Cheryl Corcoran Jeffrey A Lieberman Bradley S Peterson
author_sort	Tiziano Colibazzi
title	Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
title_short	Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
title_full	Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
title_fullStr	Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
title_full_unstemmed	Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
title_sort	anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/56985a72e3474d56adfa826caaa155b6
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Anatomical abnormalities in gray and white matter of the cortical surface in persons with schizophrenia.

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