Crystal structure of an RNA-cleaving DNAzyme

RNA-cleaving DNA enzymes are catalytic DNA that can cleave RNA in a sequence-specific manner. Here, the authors report three crystal structures of the 8–17 DNAzyme that include the pre-catalytic state of the RNA cleavage reaction, providing insight into the catalytic mechanism and may guide the rati...

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Autores principales:	Hehua Liu, Xiang Yu, Yiqing Chen, Jing Zhang, Baixing Wu, Lina Zheng, Phensinee Haruehanroengra, Rui Wang, Suhua Li, Jinzhong Lin, Jixi Li, Jia Sheng, Zhen Huang, Jinbiao Ma, Jianhua Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/569952859de44152927b432d9f1d3c01
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spelling	oai:doaj.org-article:569952859de44152927b432d9f1d3c012021-12-02T14:42:22ZCrystal structure of an RNA-cleaving DNAzyme10.1038/s41467-017-02203-x2041-1723https://doaj.org/article/569952859de44152927b432d9f1d3c012017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02203-xhttps://doaj.org/toc/2041-1723RNA-cleaving DNA enzymes are catalytic DNA that can cleave RNA in a sequence-specific manner. Here, the authors report three crystal structures of the 8–17 DNAzyme that include the pre-catalytic state of the RNA cleavage reaction, providing insight into the catalytic mechanism and may guide the rational design of DNAzymes.Hehua LiuXiang YuYiqing ChenJing ZhangBaixing WuLina ZhengPhensinee HaruehanroengraRui WangSuhua LiJinzhong LinJixi LiJia ShengZhen HuangJinbiao MaJianhua GanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hehua Liu Xiang Yu Yiqing Chen Jing Zhang Baixing Wu Lina Zheng Phensinee Haruehanroengra Rui Wang Suhua Li Jinzhong Lin Jixi Li Jia Sheng Zhen Huang Jinbiao Ma Jianhua Gan Crystal structure of an RNA-cleaving DNAzyme
description	RNA-cleaving DNA enzymes are catalytic DNA that can cleave RNA in a sequence-specific manner. Here, the authors report three crystal structures of the 8–17 DNAzyme that include the pre-catalytic state of the RNA cleavage reaction, providing insight into the catalytic mechanism and may guide the rational design of DNAzymes.
format	article
author	Hehua Liu Xiang Yu Yiqing Chen Jing Zhang Baixing Wu Lina Zheng Phensinee Haruehanroengra Rui Wang Suhua Li Jinzhong Lin Jixi Li Jia Sheng Zhen Huang Jinbiao Ma Jianhua Gan
author_facet	Hehua Liu Xiang Yu Yiqing Chen Jing Zhang Baixing Wu Lina Zheng Phensinee Haruehanroengra Rui Wang Suhua Li Jinzhong Lin Jixi Li Jia Sheng Zhen Huang Jinbiao Ma Jianhua Gan
author_sort	Hehua Liu
title	Crystal structure of an RNA-cleaving DNAzyme
title_short	Crystal structure of an RNA-cleaving DNAzyme
title_full	Crystal structure of an RNA-cleaving DNAzyme
title_fullStr	Crystal structure of an RNA-cleaving DNAzyme
title_full_unstemmed	Crystal structure of an RNA-cleaving DNAzyme
title_sort	crystal structure of an rna-cleaving dnazyme
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/569952859de44152927b432d9f1d3c01
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_version_	1718389689364250624

Crystal structure of an RNA-cleaving DNAzyme

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