Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study
Purpose: This study aimed to evaluate the prognostic impact of vascular invasion (VI) in comparison with that of lymph node metastasis (LNM) in non-metastatic colon cancer.Methods: Patients who underwent curative surgery for stage I-III colon cancer were divided into four groups depending on the sta...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:56998336b27a4bf78dd076f483c90ae72021-11-10T06:02:11ZComparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study2296-875X10.3389/fsurg.2021.773019https://doaj.org/article/56998336b27a4bf78dd076f483c90ae72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.773019/fullhttps://doaj.org/toc/2296-875XPurpose: This study aimed to evaluate the prognostic impact of vascular invasion (VI) in comparison with that of lymph node metastasis (LNM) in non-metastatic colon cancer.Methods: Patients who underwent curative surgery for stage I-III colon cancer were divided into four groups depending on the status of VI and LNM (Group I: VI-/LNM-; Group II: VI+/LNM-; Group III: VI-/LNM+; Group IV: VI+/LNM+). Group III was subdivided according to the nodal (N) stage (Group IIIA: VI-/N1; Group IIIB: VI-/N2). Oncological outcomes were compared between Groups II and III.Results: In total, 793 non-metastatic colon cancer patients were included. Group II [hazard ratio (HR) 2.34, 1.01–5.41] and Group III (HR 1.91, 1.26–2.89) were independently associated with poor disease-free survival (DFS). The 5-year DFS rates were comparable in Groups II (71.6%) and III (72.5%) (P = 0.637). When Group III was subdivided into Groups IIIA and IIIB, DFS deteriorated in the following order: Groups IIIA, II, and IIIB. The 5-year DFS rates were 79.7, 71.6, and 61.4% in Groups IIIA, II, and IIIB, respectively. Group II had a tendency toward early recurrence. The 1- and 2-year DFS rates were 76.3 and 71.6% in Group II and 88.3 and 79.8% in Group III, respectively (P = 0.067 and 0.247). All recurrences in Group II were distant metastases.Conclusion: VI is a prognostic factor as significant as LNM and may be a stronger prognostic factor than N1 stage in non-metastatic colon cancer. Furthermore, a potential association was observed between VI and recurrence patterns, such as early recurrence and distant metastasis.Jung Hoon BaeJi Hoon KimBong-Hyeon KyeAbdullah Al-SawatChul Seung LeeSeung-Rim HanIn Kyu LeeSung Hak LeeYoon Suk LeeFrontiers Media S.A.articlecolonic neoplasmsvascular invasionlymph node metastasisprognosisrecurrenceSurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021) |
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colonic neoplasms vascular invasion lymph node metastasis prognosis recurrence Surgery RD1-811 |
| spellingShingle |
colonic neoplasms vascular invasion lymph node metastasis prognosis recurrence Surgery RD1-811 Jung Hoon Bae Ji Hoon Kim Bong-Hyeon Kye Abdullah Al-Sawat Chul Seung Lee Seung-Rim Han In Kyu Lee Sung Hak Lee Yoon Suk Lee Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study |
| description |
Purpose: This study aimed to evaluate the prognostic impact of vascular invasion (VI) in comparison with that of lymph node metastasis (LNM) in non-metastatic colon cancer.Methods: Patients who underwent curative surgery for stage I-III colon cancer were divided into four groups depending on the status of VI and LNM (Group I: VI-/LNM-; Group II: VI+/LNM-; Group III: VI-/LNM+; Group IV: VI+/LNM+). Group III was subdivided according to the nodal (N) stage (Group IIIA: VI-/N1; Group IIIB: VI-/N2). Oncological outcomes were compared between Groups II and III.Results: In total, 793 non-metastatic colon cancer patients were included. Group II [hazard ratio (HR) 2.34, 1.01–5.41] and Group III (HR 1.91, 1.26–2.89) were independently associated with poor disease-free survival (DFS). The 5-year DFS rates were comparable in Groups II (71.6%) and III (72.5%) (P = 0.637). When Group III was subdivided into Groups IIIA and IIIB, DFS deteriorated in the following order: Groups IIIA, II, and IIIB. The 5-year DFS rates were 79.7, 71.6, and 61.4% in Groups IIIA, II, and IIIB, respectively. Group II had a tendency toward early recurrence. The 1- and 2-year DFS rates were 76.3 and 71.6% in Group II and 88.3 and 79.8% in Group III, respectively (P = 0.067 and 0.247). All recurrences in Group II were distant metastases.Conclusion: VI is a prognostic factor as significant as LNM and may be a stronger prognostic factor than N1 stage in non-metastatic colon cancer. Furthermore, a potential association was observed between VI and recurrence patterns, such as early recurrence and distant metastasis. |
| format |
article |
| author |
Jung Hoon Bae Ji Hoon Kim Bong-Hyeon Kye Abdullah Al-Sawat Chul Seung Lee Seung-Rim Han In Kyu Lee Sung Hak Lee Yoon Suk Lee |
| author_facet |
Jung Hoon Bae Ji Hoon Kim Bong-Hyeon Kye Abdullah Al-Sawat Chul Seung Lee Seung-Rim Han In Kyu Lee Sung Hak Lee Yoon Suk Lee |
| author_sort |
Jung Hoon Bae |
| title |
Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study |
| title_short |
Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study |
| title_full |
Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study |
| title_fullStr |
Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study |
| title_full_unstemmed |
Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study |
| title_sort |
comparison of vascular invasion with lymph node metastasis as a prognostic factor in stage i-iii colon cancer: an observational cohort study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/56998336b27a4bf78dd076f483c90ae7 |
| work_keys_str_mv |
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