Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers

Abstract The honey bee acetylcholinesterase 1 (AmAChE1) has been suggested to be related to stress response as judged from its elevated expression level under brood rearing-suppressed conditions. To further investigate the involvement of AmAChE1 expression in the stress response and its physiologica...

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Autores principales:	Sanghyeon Kim, Kyungmun Kim, Jae Ho Lee, Seung Hee Han, Si Hyeock Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/569b660a78eb4e189d0f3f83a1ae106b
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spelling	oai:doaj.org-article:569b660a78eb4e189d0f3f83a1ae106b2021-12-02T15:08:59ZDifferential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers10.1038/s41598-019-46842-02045-2322https://doaj.org/article/569b660a78eb4e189d0f3f83a1ae106b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46842-0https://doaj.org/toc/2045-2322Abstract The honey bee acetylcholinesterase 1 (AmAChE1) has been suggested to be related to stress response as judged from its elevated expression level under brood rearing-suppressed conditions. To further investigate the involvement of AmAChE1 expression in the stress response and its physiological functions, we analyzed altered expression profiles of AmAChE1 induced by diverse stress factors. In addition, transcription profiles of several heat shock protein (Hsp) genes (hsps) and the vitellogenin (Vg) gene (vg) known as general stress markers were investigated as positive references. Among the tested stress conditions, AmAChE1 expression was induced under the brood rearing-suppressed, crowding and heat shock conditions. The hsps, particularly hsp70 and hsp90, responded to seven of nine stress conditions tested, confirming that hsp expression profiles can serve as a general stress marker. Taken together, AmAChE1 expression is not suitable for using as a stress marker due to its limited response. Nevertheless, AmAChE1 expression appears to be connected, at least in part, to heat shock response and other pathways. Considering that AmAChE1 likely regulates the ACh titer particularly in non-neuronal tissues, thereby modulating the signal cascades mediated by mAChR, the AmAChE1 expression profile under different conditions likely provides important information on its physiological roles in honey bees.Sanghyeon KimKyungmun KimJae Ho LeeSeung Hee HanSi Hyeock LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanghyeon Kim Kyungmun Kim Jae Ho Lee Seung Hee Han Si Hyeock Lee Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
description	Abstract The honey bee acetylcholinesterase 1 (AmAChE1) has been suggested to be related to stress response as judged from its elevated expression level under brood rearing-suppressed conditions. To further investigate the involvement of AmAChE1 expression in the stress response and its physiological functions, we analyzed altered expression profiles of AmAChE1 induced by diverse stress factors. In addition, transcription profiles of several heat shock protein (Hsp) genes (hsps) and the vitellogenin (Vg) gene (vg) known as general stress markers were investigated as positive references. Among the tested stress conditions, AmAChE1 expression was induced under the brood rearing-suppressed, crowding and heat shock conditions. The hsps, particularly hsp70 and hsp90, responded to seven of nine stress conditions tested, confirming that hsp expression profiles can serve as a general stress marker. Taken together, AmAChE1 expression is not suitable for using as a stress marker due to its limited response. Nevertheless, AmAChE1 expression appears to be connected, at least in part, to heat shock response and other pathways. Considering that AmAChE1 likely regulates the ACh titer particularly in non-neuronal tissues, thereby modulating the signal cascades mediated by mAChR, the AmAChE1 expression profile under different conditions likely provides important information on its physiological roles in honey bees.
format	article
author	Sanghyeon Kim Kyungmun Kim Jae Ho Lee Seung Hee Han Si Hyeock Lee
author_facet	Sanghyeon Kim Kyungmun Kim Jae Ho Lee Seung Hee Han Si Hyeock Lee
author_sort	Sanghyeon Kim
title	Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
title_short	Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
title_full	Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
title_fullStr	Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
title_full_unstemmed	Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
title_sort	differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/569b660a78eb4e189d0f3f83a1ae106b
work_keys_str_mv	AT sanghyeonkim differentialexpressionofacetylcholinesterase1inresponsetovariousstressfactorsinhoneybeeworkers AT kyungmunkim differentialexpressionofacetylcholinesterase1inresponsetovariousstressfactorsinhoneybeeworkers AT jaeholee differentialexpressionofacetylcholinesterase1inresponsetovariousstressfactorsinhoneybeeworkers AT seungheehan differentialexpressionofacetylcholinesterase1inresponsetovariousstressfactorsinhoneybeeworkers AT sihyeocklee differentialexpressionofacetylcholinesterase1inresponsetovariousstressfactorsinhoneybeeworkers
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Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers

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