Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.

Whether unique to humans or not, consciousness is a central aspect of our experience of the world. The neural fingerprint of this experience, however, remains one of the least understood aspects of the human brain. In this paper we employ graph-theoretic measures and support vector machine classific...

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Autores principales:	Martin M Monti, Evan S Lutkenhoff, Mikail Rubinov, Pierre Boveroux, Audrey Vanhaudenhuyse, Olivia Gosseries, Marie-Aurélie Bruno, Quentin Noirhomme, Mélanie Boly, Steven Laureys
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/56a1fdd507e54d76bf06cf82abed8ab3
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spelling	oai:doaj.org-article:56a1fdd507e54d76bf06cf82abed8ab32021-11-18T05:53:30ZDynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.1553-734X1553-735810.1371/journal.pcbi.1003271https://doaj.org/article/56a1fdd507e54d76bf06cf82abed8ab32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24146606/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Whether unique to humans or not, consciousness is a central aspect of our experience of the world. The neural fingerprint of this experience, however, remains one of the least understood aspects of the human brain. In this paper we employ graph-theoretic measures and support vector machine classification to assess, in 12 healthy volunteers, the dynamic reconfiguration of functional connectivity during wakefulness, propofol-induced sedation and loss of consciousness, and the recovery of wakefulness. Our main findings, based on resting-state fMRI, are three-fold. First, we find that propofol-induced anesthesia does not bear differently on long-range versus short-range connections. Second, our multi-stage design dissociated an initial phase of thalamo-cortical and cortico-cortical hyperconnectivity, present during sedation, from a phase of cortico-cortical hypoconnectivity, apparent during loss of consciousness. Finally, we show that while clustering is increased during loss of consciousness, as recently suggested, it also remains significantly elevated during wakefulness recovery. Conversely, the characteristic path length of brain networks (i.e., the average functional distance between any two regions of the brain) appears significantly increased only during loss of consciousness, marking a decrease of global information-processing efficiency uniquely associated with unconsciousness. These findings suggest that propofol-induced loss of consciousness is mainly tied to cortico-cortical and not thalamo-cortical mechanisms, and that decreased efficiency of information flow is the main feature differentiating the conscious from the unconscious brain.Martin M MontiEvan S LutkenhoffMikail RubinovPierre BoverouxAudrey VanhaudenhuyseOlivia GosseriesMarie-Aurélie BrunoQuentin NoirhommeMélanie BolySteven LaureysPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 10, p e1003271 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Martin M Monti Evan S Lutkenhoff Mikail Rubinov Pierre Boveroux Audrey Vanhaudenhuyse Olivia Gosseries Marie-Aurélie Bruno Quentin Noirhomme Mélanie Boly Steven Laureys Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
description	Whether unique to humans or not, consciousness is a central aspect of our experience of the world. The neural fingerprint of this experience, however, remains one of the least understood aspects of the human brain. In this paper we employ graph-theoretic measures and support vector machine classification to assess, in 12 healthy volunteers, the dynamic reconfiguration of functional connectivity during wakefulness, propofol-induced sedation and loss of consciousness, and the recovery of wakefulness. Our main findings, based on resting-state fMRI, are three-fold. First, we find that propofol-induced anesthesia does not bear differently on long-range versus short-range connections. Second, our multi-stage design dissociated an initial phase of thalamo-cortical and cortico-cortical hyperconnectivity, present during sedation, from a phase of cortico-cortical hypoconnectivity, apparent during loss of consciousness. Finally, we show that while clustering is increased during loss of consciousness, as recently suggested, it also remains significantly elevated during wakefulness recovery. Conversely, the characteristic path length of brain networks (i.e., the average functional distance between any two regions of the brain) appears significantly increased only during loss of consciousness, marking a decrease of global information-processing efficiency uniquely associated with unconsciousness. These findings suggest that propofol-induced loss of consciousness is mainly tied to cortico-cortical and not thalamo-cortical mechanisms, and that decreased efficiency of information flow is the main feature differentiating the conscious from the unconscious brain.
format	article
author	Martin M Monti Evan S Lutkenhoff Mikail Rubinov Pierre Boveroux Audrey Vanhaudenhuyse Olivia Gosseries Marie-Aurélie Bruno Quentin Noirhomme Mélanie Boly Steven Laureys
author_facet	Martin M Monti Evan S Lutkenhoff Mikail Rubinov Pierre Boveroux Audrey Vanhaudenhuyse Olivia Gosseries Marie-Aurélie Bruno Quentin Noirhomme Mélanie Boly Steven Laureys
author_sort	Martin M Monti
title	Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
title_short	Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
title_full	Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
title_fullStr	Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
title_full_unstemmed	Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
title_sort	dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/56a1fdd507e54d76bf06cf82abed8ab3
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Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.

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