Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows

Abstract The preparatory accommodation response of lower esophageal sphincter (LES) before swallowing is one of the mechanisms involved in LES relaxation during wet swallows, however, the physiological and/or pathological roles of LES accommodation remain to be determined in humans. To address this...

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Autores principales:	Kazumasa Muta, Eikichi Ihara, Shohei Hamada, Hiroko Ikeda, Masafumi Wada, Yoshitaka Hata, Xiaopeng Bai, Yuichiro Nishihara, Yoshimasa Tanaka, Haruei Ogino, Yoshihiro Ogawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56a3beb452e348a2a5cf5244476364dc
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spelling	oai:doaj.org-article:56a3beb452e348a2a5cf5244476364dc2021-12-02T15:51:12ZPhysiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows10.1038/s41598-021-87052-x2045-2322https://doaj.org/article/56a3beb452e348a2a5cf5244476364dc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87052-xhttps://doaj.org/toc/2045-2322Abstract The preparatory accommodation response of lower esophageal sphincter (LES) before swallowing is one of the mechanisms involved in LES relaxation during wet swallows, however, the physiological and/or pathological roles of LES accommodation remain to be determined in humans. To address this problem, we conducted a prospective observational study of 38 patients with normal high-resolution manometry (HRM) and 23 patients with idiopathic esophagogastric junction outflow obstruction (EGJOO) to assess dry and wet swallows. The LES accommodation measurement was proposed for practical use in evaluating the LES accommodation response. Although swallow-induced LES relaxation was observed in both dry and wet swallows, LES accommodation (6.4, 3.1–11.1 mmHg) was only observed in wet swallows. The extent of LES accommodation was impaired in idiopathic EGJOO (0.6, − 0.6–6 mmHg), and the LES accommodation measurement of patients with idiopathic EGJOO (36.8, 29.5–44.3 mmHg) was significantly higher in comparison to those with normal HRM (23.8, 18–28.6 mmHg). Successful LES relaxation in wet swallowing can be achieved by LES accommodation in combination with swallow-induced LES relaxation. Impaired LES accommodation is characteristic of idiopathic EGJOO. In addition to the IRP value, the LES accommodation measurement may be useful for evaluating the LES relaxation function in clinical practice.Kazumasa MutaEikichi IharaShohei HamadaHiroko IkedaMasafumi WadaYoshitaka HataXiaopeng BaiYuichiro NishiharaYoshimasa TanakaHaruei OginoYoshihiro OgawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazumasa Muta Eikichi Ihara Shohei Hamada Hiroko Ikeda Masafumi Wada Yoshitaka Hata Xiaopeng Bai Yuichiro Nishihara Yoshimasa Tanaka Haruei Ogino Yoshihiro Ogawa Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
description	Abstract The preparatory accommodation response of lower esophageal sphincter (LES) before swallowing is one of the mechanisms involved in LES relaxation during wet swallows, however, the physiological and/or pathological roles of LES accommodation remain to be determined in humans. To address this problem, we conducted a prospective observational study of 38 patients with normal high-resolution manometry (HRM) and 23 patients with idiopathic esophagogastric junction outflow obstruction (EGJOO) to assess dry and wet swallows. The LES accommodation measurement was proposed for practical use in evaluating the LES accommodation response. Although swallow-induced LES relaxation was observed in both dry and wet swallows, LES accommodation (6.4, 3.1–11.1 mmHg) was only observed in wet swallows. The extent of LES accommodation was impaired in idiopathic EGJOO (0.6, − 0.6–6 mmHg), and the LES accommodation measurement of patients with idiopathic EGJOO (36.8, 29.5–44.3 mmHg) was significantly higher in comparison to those with normal HRM (23.8, 18–28.6 mmHg). Successful LES relaxation in wet swallowing can be achieved by LES accommodation in combination with swallow-induced LES relaxation. Impaired LES accommodation is characteristic of idiopathic EGJOO. In addition to the IRP value, the LES accommodation measurement may be useful for evaluating the LES relaxation function in clinical practice.
format	article
author	Kazumasa Muta Eikichi Ihara Shohei Hamada Hiroko Ikeda Masafumi Wada Yoshitaka Hata Xiaopeng Bai Yuichiro Nishihara Yoshimasa Tanaka Haruei Ogino Yoshihiro Ogawa
author_facet	Kazumasa Muta Eikichi Ihara Shohei Hamada Hiroko Ikeda Masafumi Wada Yoshitaka Hata Xiaopeng Bai Yuichiro Nishihara Yoshimasa Tanaka Haruei Ogino Yoshihiro Ogawa
author_sort	Kazumasa Muta
title	Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
title_short	Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
title_full	Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
title_fullStr	Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
title_full_unstemmed	Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
title_sort	physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56a3beb452e348a2a5cf5244476364dc
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Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows

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