Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease

The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, <i>Ramalina terebrata<...

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Autores principales:	Tai Kyoung Kim, Ju-Mi Hong, Kyung Hee Kim, Se Jong Han, Il-Chan Kim, Hyuncheol Oh, Joung Han Yim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/56a4c1ebaf89466d94994460a20a0aca
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spelling	oai:doaj.org-article:56a4c1ebaf89466d94994460a20a0aca2021-11-11T18:27:38ZPotential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease10.3390/molecules262164451420-3049https://doaj.org/article/56a4c1ebaf89466d94994460a20a0aca2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6445https://doaj.org/toc/1420-3049The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, <i>Ramalina terebrata</i>), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.Tai Kyoung KimJu-Mi HongKyung Hee KimSe Jong HanIl-Chan KimHyuncheol OhJoung Han YimMDPI AGarticleAlzheimer’s diseaseramalinderivativestherapeutic potentialantioxidantβ-secrataseOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6445, p 6445 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase Organic chemistry QD241-441
spellingShingle	Alzheimer’s disease ramalin derivatives therapeutic potential antioxidant β-secratase Organic chemistry QD241-441 Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
description	The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, <i>Ramalina terebrata</i>), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.
format	article
author	Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim
author_facet	Tai Kyoung Kim Ju-Mi Hong Kyung Hee Kim Se Jong Han Il-Chan Kim Hyuncheol Oh Joung Han Yim
author_sort	Tai Kyoung Kim
title	Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_short	Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_full	Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_fullStr	Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_full_unstemmed	Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
title_sort	potential of ramalin and its derivatives for the treatment of alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/56a4c1ebaf89466d94994460a20a0aca
work_keys_str_mv	AT taikyoungkim potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease AT jumihong potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease AT kyungheekim potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease AT sejonghan potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease AT ilchankim potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease AT hyuncheoloh potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease AT jounghanyim potentialoframalinanditsderivativesforthetreatmentofalzheimersdisease
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Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease

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