Dendrimers functionalized with membrane-interacting peptides for viral inhibition

Rossella Tarallo,1 Tom P Carberry,2 Annarita Falanga,1 Mariateresa Vitiello,3 Stefania Galdiero,1 Massimiliano Galdiero,3 Marcus Weck21Dipartimento di Farmacia, Universit&agrave; di Napoli &quot;Federico II,&quot; and DFM Scarl, Napoli, Italia; 2Molecular Design Institute and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tarallo R, Carberry TP, Falanga A, Vitiello M, Galdiero S, Galdiero M, Weck M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/56a726a661784ecf8b04be883ec88c0a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:56a726a661784ecf8b04be883ec88c0a
record_format	dspace
spelling	oai:doaj.org-article:56a726a661784ecf8b04be883ec88c0a2021-12-02T03:11:38ZDendrimers functionalized with membrane-interacting peptides for viral inhibition1176-91141178-2013https://doaj.org/article/56a726a661784ecf8b04be883ec88c0a2013-02-01T00:00:00Zhttp://www.dovepress.com/dendrimers-functionalized-with-membrane-interacting-peptides-for-viral-a12134https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rossella Tarallo,1 Tom P Carberry,2 Annarita Falanga,1 Mariateresa Vitiello,3 Stefania Galdiero,1 Massimiliano Galdiero,3 Marcus Weck21Dipartimento di Farmacia, Universit&agrave; di Napoli &quot;Federico II,&quot; and DFM Scarl, Napoli, Italia; 2Molecular Design Institute and Department of Chemistry, New York University, New York, NY, USA; 3Dipartimento di Medicina Sperimentale, Seconda Universit&agrave; degli Studi di Napoli, Napoli, ItaliaAbstract: This contribution reports the synthesis of a poly(amide)-based dendrimer functionalized at the termini with a membrane-interacting peptide derived from the herpes simplex virus (HSV) type 1 glycoprotein H, namely gH625-644. This peptide has been shown to interact with model membranes and to inhibit viral infectivity. The peptidodendrimer inhibits both HSV-1 and HSV-2 at a very early stage of the entry process, most likely through an interaction with the viral envelope glycoproteins; thus, preventing the virus from coming into close contact with cellular membranes, a prerequisite of viral internalization. The 50% inhibitory concentration was 100 and 300 nM against HSV-1 and HSV-2 respectively, with no evidence of cell toxicity at these concentrations. These results show that the functionalization of a dendrimer with the peptide sequence derived from an HSV glycoprotein shows promising inhibitory activity towards viruses of the Herpesviridae family.Keywords: peptidodendrimer, antiviral activity, membranotropic peptidesTarallo RCarberry TPFalanga AVitiello MGaldiero SGaldiero MWeck MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 521-534 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tarallo R Carberry TP Falanga A Vitiello M Galdiero S Galdiero M Weck M Dendrimers functionalized with membrane-interacting peptides for viral inhibition
description	Rossella Tarallo,1 Tom P Carberry,2 Annarita Falanga,1 Mariateresa Vitiello,3 Stefania Galdiero,1 Massimiliano Galdiero,3 Marcus Weck21Dipartimento di Farmacia, Universit&agrave; di Napoli &quot;Federico II,&quot; and DFM Scarl, Napoli, Italia; 2Molecular Design Institute and Department of Chemistry, New York University, New York, NY, USA; 3Dipartimento di Medicina Sperimentale, Seconda Universit&agrave; degli Studi di Napoli, Napoli, ItaliaAbstract: This contribution reports the synthesis of a poly(amide)-based dendrimer functionalized at the termini with a membrane-interacting peptide derived from the herpes simplex virus (HSV) type 1 glycoprotein H, namely gH625-644. This peptide has been shown to interact with model membranes and to inhibit viral infectivity. The peptidodendrimer inhibits both HSV-1 and HSV-2 at a very early stage of the entry process, most likely through an interaction with the viral envelope glycoproteins; thus, preventing the virus from coming into close contact with cellular membranes, a prerequisite of viral internalization. The 50% inhibitory concentration was 100 and 300 nM against HSV-1 and HSV-2 respectively, with no evidence of cell toxicity at these concentrations. These results show that the functionalization of a dendrimer with the peptide sequence derived from an HSV glycoprotein shows promising inhibitory activity towards viruses of the Herpesviridae family.Keywords: peptidodendrimer, antiviral activity, membranotropic peptides
format	article
author	Tarallo R Carberry TP Falanga A Vitiello M Galdiero S Galdiero M Weck M
author_facet	Tarallo R Carberry TP Falanga A Vitiello M Galdiero S Galdiero M Weck M
author_sort	Tarallo R
title	Dendrimers functionalized with membrane-interacting peptides for viral inhibition
title_short	Dendrimers functionalized with membrane-interacting peptides for viral inhibition
title_full	Dendrimers functionalized with membrane-interacting peptides for viral inhibition
title_fullStr	Dendrimers functionalized with membrane-interacting peptides for viral inhibition
title_full_unstemmed	Dendrimers functionalized with membrane-interacting peptides for viral inhibition
title_sort	dendrimers functionalized with membrane-interacting peptides for viral inhibition
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/56a726a661784ecf8b04be883ec88c0a
work_keys_str_mv	AT tarallor dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition AT carberrytp dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition AT falangaa dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition AT vitiellom dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition AT galdieros dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition AT galdierom dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition AT weckm dendrimersfunctionalizedwithmembraneinteractingpeptidesforviralinhibition
_version_	1718401853931126784

Dendrimers functionalized with membrane-interacting peptides for viral inhibition

Ejemplares similares