Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting enzym...

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Autores principales:	Jianlin Zuo, Jinshuo Tang, Meng Lu, Zhongsheng Zhou, Yang Li, Hao Tian, Enbo Liu, Baoying Gao, Te Liu, Pu Shao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	glycolysis rate-limiting enzymes rheumatoid arthritis RA pathogenesis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/56a985fa504340e098a0387dd03a95d7
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spelling	oai:doaj.org-article:56a985fa504340e098a0387dd03a95d72021-11-30T17:42:25ZGlycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis1664-322410.3389/fimmu.2021.779787https://doaj.org/article/56a985fa504340e098a0387dd03a95d72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.779787/fullhttps://doaj.org/toc/1664-3224Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting enzymes, hexokinase-II (HK-II), phosphofructokinase-1 (PFK-1), and pyruvate kinase M2 (PKM2), as well as indirect rate-limiting enzymes, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), are thought to participate in the pathogenesis of RA. In here, we review the latest literature on the pathogenesis of RA, introduce the pathophysiological characteristics of HK-II, PFK-1/PFKFB3, and PKM2 and their expression characteristics in this autoimmune disease, and systematically assess the association between the glycolytic rate-limiting enzymes and RA from a molecular level. Moreover, we highlight HK-II, PFK-1/PFKFB3, and PKM2 as potential targets for the clinical treatment of RA. There is great potential to develop new anti-rheumatic therapies through safe inhibition or overexpression of glycolysis rate-limiting enzymes.Jianlin ZuoJinshuo TangMeng LuZhongsheng ZhouYang LiHao TianEnbo LiuBaoying GaoTe LiuPu ShaoPu ShaoFrontiers Media S.A.articleglycolysisrate-limiting enzymesrheumatoid arthritisRApathogenesisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycolysis rate-limiting enzymes rheumatoid arthritis RA pathogenesis Immunologic diseases. Allergy RC581-607
spellingShingle	glycolysis rate-limiting enzymes rheumatoid arthritis RA pathogenesis Immunologic diseases. Allergy RC581-607 Jianlin Zuo Jinshuo Tang Meng Lu Zhongsheng Zhou Yang Li Hao Tian Enbo Liu Baoying Gao Te Liu Pu Shao Pu Shao Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
description	Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting enzymes, hexokinase-II (HK-II), phosphofructokinase-1 (PFK-1), and pyruvate kinase M2 (PKM2), as well as indirect rate-limiting enzymes, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), are thought to participate in the pathogenesis of RA. In here, we review the latest literature on the pathogenesis of RA, introduce the pathophysiological characteristics of HK-II, PFK-1/PFKFB3, and PKM2 and their expression characteristics in this autoimmune disease, and systematically assess the association between the glycolytic rate-limiting enzymes and RA from a molecular level. Moreover, we highlight HK-II, PFK-1/PFKFB3, and PKM2 as potential targets for the clinical treatment of RA. There is great potential to develop new anti-rheumatic therapies through safe inhibition or overexpression of glycolysis rate-limiting enzymes.
format	article
author	Jianlin Zuo Jinshuo Tang Meng Lu Zhongsheng Zhou Yang Li Hao Tian Enbo Liu Baoying Gao Te Liu Pu Shao Pu Shao
author_facet	Jianlin Zuo Jinshuo Tang Meng Lu Zhongsheng Zhou Yang Li Hao Tian Enbo Liu Baoying Gao Te Liu Pu Shao Pu Shao
author_sort	Jianlin Zuo
title	Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
title_short	Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
title_full	Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
title_fullStr	Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
title_full_unstemmed	Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
title_sort	glycolysis rate-limiting enzymes: novel potential regulators of rheumatoid arthritis pathogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/56a985fa504340e098a0387dd03a95d7
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Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

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