Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes

Computational algorithms to infer chromatin sub-compartments and compartment domains require high-resolution Hi-C maps. Here the authors present Calder, an algorithm that can infer sub-compartments and compartment domains with variable resolution Hi-C data, and they apply it to more than a hundred H...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuanlong Liu, Luca Nanni, Stephanie Sungalee, Marie Zufferey, Daniele Tavernari, Marco Mina, Stefano Ceri, Elisa Oricchio, Giovanni Ciriello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56a9e0c094de41b29bd307369b8ec6b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:56a9e0c094de41b29bd307369b8ec6b3
record_format	dspace
spelling	oai:doaj.org-article:56a9e0c094de41b29bd307369b8ec6b32021-12-02T15:36:28ZSystematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes10.1038/s41467-021-22666-32041-1723https://doaj.org/article/56a9e0c094de41b29bd307369b8ec6b32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22666-3https://doaj.org/toc/2041-1723Computational algorithms to infer chromatin sub-compartments and compartment domains require high-resolution Hi-C maps. Here the authors present Calder, an algorithm that can infer sub-compartments and compartment domains with variable resolution Hi-C data, and they apply it to more than a hundred Hi-C experiments to study sub-compartment repositioning.Yuanlong LiuLuca NanniStephanie SungaleeMarie ZuffereyDaniele TavernariMarco MinaStefano CeriElisa OricchioGiovanni CirielloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanlong Liu Luca Nanni Stephanie Sungalee Marie Zufferey Daniele Tavernari Marco Mina Stefano Ceri Elisa Oricchio Giovanni Ciriello Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
description	Computational algorithms to infer chromatin sub-compartments and compartment domains require high-resolution Hi-C maps. Here the authors present Calder, an algorithm that can infer sub-compartments and compartment domains with variable resolution Hi-C data, and they apply it to more than a hundred Hi-C experiments to study sub-compartment repositioning.
format	article
author	Yuanlong Liu Luca Nanni Stephanie Sungalee Marie Zufferey Daniele Tavernari Marco Mina Stefano Ceri Elisa Oricchio Giovanni Ciriello
author_facet	Yuanlong Liu Luca Nanni Stephanie Sungalee Marie Zufferey Daniele Tavernari Marco Mina Stefano Ceri Elisa Oricchio Giovanni Ciriello
author_sort	Yuanlong Liu
title	Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
title_short	Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
title_full	Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
title_fullStr	Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
title_full_unstemmed	Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
title_sort	systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56a9e0c094de41b29bd307369b8ec6b3
work_keys_str_mv	AT yuanlongliu systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT lucananni systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT stephaniesungalee systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT mariezufferey systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT danieletavernari systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT marcomina systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT stefanoceri systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT elisaoricchio systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes AT giovanniciriello systematicinferenceandcomparisonofmultiscalechromatinsubcompartmentsconnectsspatialorganizationtocellphenotypes
_version_	1718386289307287552

Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes

Ejemplares similares