Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
The rate of repair declines with age; however, exposure to young circulations can rejuvenate fracture repair, but how this is accomplished is unknown. Here, the authors identify proteins, including low-density lipoprotein receptor-related protein 1 (Lrp1), as being secreted from young macrophages an...
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Nature Portfolio
2018
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oai:doaj.org-article:56adb114e6924a34bf6b3b26daebff262021-12-02T16:56:53ZMacrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice10.1038/s41467-018-07666-02041-1723https://doaj.org/article/56adb114e6924a34bf6b3b26daebff262018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07666-0https://doaj.org/toc/2041-1723The rate of repair declines with age; however, exposure to young circulations can rejuvenate fracture repair, but how this is accomplished is unknown. Here, the authors identify proteins, including low-density lipoprotein receptor-related protein 1 (Lrp1), as being secreted from young macrophages and rejuvenating fracture repair in mice.Linda ViGurpreet S. BahtErik J. SoderblomHeather WhetstoneQingxia WeiBridgette FurmanVijitha PuviindranPuviindran NadesanMatthew FosterRaymond PoonJames P. WhiteYasuhito YaharaAdeline NgTomasa BarrientosMarc GrynpasM. Arthur MoselyBenjamin A. AlmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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DOAJ |
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DOAJ |
| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Linda Vi Gurpreet S. Baht Erik J. Soderblom Heather Whetstone Qingxia Wei Bridgette Furman Vijitha Puviindran Puviindran Nadesan Matthew Foster Raymond Poon James P. White Yasuhito Yahara Adeline Ng Tomasa Barrientos Marc Grynpas M. Arthur Mosely Benjamin A. Alman Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice |
| description |
The rate of repair declines with age; however, exposure to young circulations can rejuvenate fracture repair, but how this is accomplished is unknown. Here, the authors identify proteins, including low-density lipoprotein receptor-related protein 1 (Lrp1), as being secreted from young macrophages and rejuvenating fracture repair in mice. |
| format |
article |
| author |
Linda Vi Gurpreet S. Baht Erik J. Soderblom Heather Whetstone Qingxia Wei Bridgette Furman Vijitha Puviindran Puviindran Nadesan Matthew Foster Raymond Poon James P. White Yasuhito Yahara Adeline Ng Tomasa Barrientos Marc Grynpas M. Arthur Mosely Benjamin A. Alman |
| author_facet |
Linda Vi Gurpreet S. Baht Erik J. Soderblom Heather Whetstone Qingxia Wei Bridgette Furman Vijitha Puviindran Puviindran Nadesan Matthew Foster Raymond Poon James P. White Yasuhito Yahara Adeline Ng Tomasa Barrientos Marc Grynpas M. Arthur Mosely Benjamin A. Alman |
| author_sort |
Linda Vi |
| title |
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice |
| title_short |
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice |
| title_full |
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice |
| title_fullStr |
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice |
| title_full_unstemmed |
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice |
| title_sort |
macrophage cells secrete factors including lrp1 that orchestrate the rejuvenation of bone repair in mice |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/56adb114e6924a34bf6b3b26daebff26 |
| work_keys_str_mv |
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