A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies

Faster, higher throughput antibody engineering methods are needed. Here the authors present CeVICA, a cell-free nanobody engineering platform using ribosome display and computational clustering analysis for in vitro selection; they use this to develop nanobodies against the RBD of SARS-CoV-2 spike p...

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Auteurs principaux:	Xun Chen, Matteo Gentili, Nir Hacohen, Aviv Regev
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/56b2b7942e424f41b5a4614d612ffcf2
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id	oai:doaj.org-article:56b2b7942e424f41b5a4614d612ffcf2
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spelling	oai:doaj.org-article:56b2b7942e424f41b5a4614d612ffcf22021-12-02T18:02:33ZA cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies10.1038/s41467-021-25777-z2041-1723https://doaj.org/article/56b2b7942e424f41b5a4614d612ffcf22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25777-zhttps://doaj.org/toc/2041-1723Faster, higher throughput antibody engineering methods are needed. Here the authors present CeVICA, a cell-free nanobody engineering platform using ribosome display and computational clustering analysis for in vitro selection; they use this to develop nanobodies against the RBD of SARS-CoV-2 spike protein.Xun ChenMatteo GentiliNir HacohenAviv RegevNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xun Chen Matteo Gentili Nir Hacohen Aviv Regev A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
description	Faster, higher throughput antibody engineering methods are needed. Here the authors present CeVICA, a cell-free nanobody engineering platform using ribosome display and computational clustering analysis for in vitro selection; they use this to develop nanobodies against the RBD of SARS-CoV-2 spike protein.
format	article
author	Xun Chen Matteo Gentili Nir Hacohen Aviv Regev
author_facet	Xun Chen Matteo Gentili Nir Hacohen Aviv Regev
author_sort	Xun Chen
title	A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
title_short	A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
title_full	A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
title_fullStr	A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
title_full_unstemmed	A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
title_sort	cell-free nanobody engineering platform rapidly generates sars-cov-2 neutralizing nanobodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56b2b7942e424f41b5a4614d612ffcf2
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A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies

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