INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C

Abstract. Detection of circulating autoantibodies provides valuable diagnostic criteria for autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). In this study, a panel of autoantibodies (ANA, ASMA, AMA) and ANCA was determined by indirect immunofluorescence assay in 191 patients, includin...

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Autores principales:	K. L. Raikhelson, U. A. Mitelglik, A. S. Zubareva, N. V. Dunaeva, T. V. Bulgakova, S. V. Lapin, A. Yu. Baranovsky, A. Totolian Areg
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	laboratory diagnostics autoantibodies autoimmune hepatitis primary biliary cirrhosis chronic hepatitis c Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/56b3e3175d4c41ebb8a7c84775b38c51
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spelling	oai:doaj.org-article:56b3e3175d4c41ebb8a7c84775b38c512021-11-18T08:03:43ZINCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C1563-06252313-741X10.15789/1563-0625-2013-4-351-360https://doaj.org/article/56b3e3175d4c41ebb8a7c84775b38c512014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/646https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Detection of circulating autoantibodies provides valuable diagnostic criteria for autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). In this study, a panel of autoantibodies (ANA, ASMA, AMA) and ANCA was determined by indirect immunofluorescence assay in 191 patients, including those with AIH type 1 (n = 42), with PBC (n = 39), with overlapping AIH-1/PBC syndrome (n = 20), and 100 patients with viral hepatitis С (HCV). Autoantibodies against PDC/AMA-M2, M2-3E, PML, Sp100, gp210, SSA-Ro52, SLA/LP, LC-1 were detected by means of immune blotting in 53 patients with autoimmune liver diseases (AIH, 19; PBC, 23; AIH/PBC, 11). ANA were detected in 88.1% of AIH-1 patients, 89.7% of PBC cases, and 100% of combined AIH-1/PBC syndrome, with highest ANA titers observed in the latter group. In patients with HCV, ANA were detected in 20%, and ASMA in 2% of the cases.ASMA and ANCA were found in monovariant AIH only (61.9% for ASMA, р < 0.001), and 35.7% for ANCA (р < 0.01). Anti-SLA/LP were detected in 15% of AIH patients, mostly with negative ANA and ASMA. PDC/AMA-M2 were identified in all patients with PBC and AIH-1/PBC, whereas AMA was detectable in 84.6% of PBC patients. Anti-M2-3E antibodies were found only in patients with PBC including those with an overlap syndrome. Occurence of detectable antibodies to gp210, Sp100, PML and SSA-Ro52 was similar in all groups. In our study, we have not confirmed a view that anti-gp210 and anti-Sp100 antibodies are highly specific for primary biliary cirrhosis.K. L. RaikhelsonU. A. MitelglikA. S. ZubarevaN. V. DunaevaT. V. BulgakovaS. V. LapinA. Yu. BaranovskyA. Totolian AregSPb RAACIarticlelaboratory diagnosticsautoantibodiesautoimmune hepatitisprimary biliary cirrhosischronic hepatitis cImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 4, Pp 351-360 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	laboratory diagnostics autoantibodies autoimmune hepatitis primary biliary cirrhosis chronic hepatitis c Immunologic diseases. Allergy RC581-607
spellingShingle	laboratory diagnostics autoantibodies autoimmune hepatitis primary biliary cirrhosis chronic hepatitis c Immunologic diseases. Allergy RC581-607 K. L. Raikhelson U. A. Mitelglik A. S. Zubareva N. V. Dunaeva T. V. Bulgakova S. V. Lapin A. Yu. Baranovsky A. Totolian Areg INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C
description	Abstract. Detection of circulating autoantibodies provides valuable diagnostic criteria for autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). In this study, a panel of autoantibodies (ANA, ASMA, AMA) and ANCA was determined by indirect immunofluorescence assay in 191 patients, including those with AIH type 1 (n = 42), with PBC (n = 39), with overlapping AIH-1/PBC syndrome (n = 20), and 100 patients with viral hepatitis С (HCV). Autoantibodies against PDC/AMA-M2, M2-3E, PML, Sp100, gp210, SSA-Ro52, SLA/LP, LC-1 were detected by means of immune blotting in 53 patients with autoimmune liver diseases (AIH, 19; PBC, 23; AIH/PBC, 11). ANA were detected in 88.1% of AIH-1 patients, 89.7% of PBC cases, and 100% of combined AIH-1/PBC syndrome, with highest ANA titers observed in the latter group. In patients with HCV, ANA were detected in 20%, and ASMA in 2% of the cases.ASMA and ANCA were found in monovariant AIH only (61.9% for ASMA, р < 0.001), and 35.7% for ANCA (р < 0.01). Anti-SLA/LP were detected in 15% of AIH patients, mostly with negative ANA and ASMA. PDC/AMA-M2 were identified in all patients with PBC and AIH-1/PBC, whereas AMA was detectable in 84.6% of PBC patients. Anti-M2-3E antibodies were found only in patients with PBC including those with an overlap syndrome. Occurence of detectable antibodies to gp210, Sp100, PML and SSA-Ro52 was similar in all groups. In our study, we have not confirmed a view that anti-gp210 and anti-Sp100 antibodies are highly specific for primary biliary cirrhosis.
format	article
author	K. L. Raikhelson U. A. Mitelglik A. S. Zubareva N. V. Dunaeva T. V. Bulgakova S. V. Lapin A. Yu. Baranovsky A. Totolian Areg
author_facet	K. L. Raikhelson U. A. Mitelglik A. S. Zubareva N. V. Dunaeva T. V. Bulgakova S. V. Lapin A. Yu. Baranovsky A. Totolian Areg
author_sort	K. L. Raikhelson
title	INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C
title_short	INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C
title_full	INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C
title_fullStr	INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C
title_full_unstemmed	INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C
title_sort	incidence of autoantibodies in patients with autoimmune liver diseases and chronic hepatitis c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/56b3e3175d4c41ebb8a7c84775b38c51
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INCIDENCE OF AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE LIVER DISEASES AND CHRONIC HEPATITIS C

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