Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.

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Autores principales: Polina Denichenko, Maxim Mogilevsky, Antoine Cléry, Thomas Welte, Jakob Biran, Odelia Shimshon, Georgina D. Barnabas, Miri Danan-Gotthold, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Frédéric H. Allain, Tamar Geiger, Gil Levkowitz, Rotem Karni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/56b48a0782e64173831607d2f384bb24
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spelling oai:doaj.org-article:56b48a0782e64173831607d2f384bb242021-12-02T16:57:21ZSpecific inhibition of splicing factor activity by decoy RNA oligonucleotides10.1038/s41467-019-09523-02041-1723https://doaj.org/article/56b48a0782e64173831607d2f384bb242019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09523-0https://doaj.org/toc/2041-1723Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.Polina DenichenkoMaxim MogilevskyAntoine CléryThomas WelteJakob BiranOdelia ShimshonGeorgina D. BarnabasMiri Danan-GottholdSaran KumarEylon YavinErez Y. LevanonFrédéric H. AllainTamar GeigerGil LevkowitzRotem KarniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Polina Denichenko
Maxim Mogilevsky
Antoine Cléry
Thomas Welte
Jakob Biran
Odelia Shimshon
Georgina D. Barnabas
Miri Danan-Gotthold
Saran Kumar
Eylon Yavin
Erez Y. Levanon
Frédéric H. Allain
Tamar Geiger
Gil Levkowitz
Rotem Karni
Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
description Alternative splicing, critical for gene expression, is deregulated in many diseases. Here the authors develop decoy oligonucleotides to specifically downregulate splicing factors activity.
format article
author Polina Denichenko
Maxim Mogilevsky
Antoine Cléry
Thomas Welte
Jakob Biran
Odelia Shimshon
Georgina D. Barnabas
Miri Danan-Gotthold
Saran Kumar
Eylon Yavin
Erez Y. Levanon
Frédéric H. Allain
Tamar Geiger
Gil Levkowitz
Rotem Karni
author_facet Polina Denichenko
Maxim Mogilevsky
Antoine Cléry
Thomas Welte
Jakob Biran
Odelia Shimshon
Georgina D. Barnabas
Miri Danan-Gotthold
Saran Kumar
Eylon Yavin
Erez Y. Levanon
Frédéric H. Allain
Tamar Geiger
Gil Levkowitz
Rotem Karni
author_sort Polina Denichenko
title Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
title_short Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
title_full Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
title_fullStr Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
title_full_unstemmed Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
title_sort specific inhibition of splicing factor activity by decoy rna oligonucleotides
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/56b48a0782e64173831607d2f384bb24
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