Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis

Abstract The current work aimed to examine the properties of oral supplementation of niacinamide and undenatured type II collagen (UCII) on the inflammation and joint pain behavior of rats with osteoarthritis (OA). Forty-nine Wistar rats were allocated into seven groups; control (no MIA), MIA as a n...

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Autores principales:	Kazim Sahin, Osman Kucuk, Cemal Orhan, Mehmet Tuzcu, Ali Said Durmus, Ibrahim Hanifi Ozercan, Nurhan Sahin, Vijaya Juturu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56b4fa05c2f449798b6cc6935d54c1af
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spelling	oai:doaj.org-article:56b4fa05c2f449798b6cc6935d54c1af2021-12-02T17:56:56ZNiacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis10.1038/s41598-021-94142-32045-2322https://doaj.org/article/56b4fa05c2f449798b6cc6935d54c1af2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94142-3https://doaj.org/toc/2045-2322Abstract The current work aimed to examine the properties of oral supplementation of niacinamide and undenatured type II collagen (UCII) on the inflammation and joint pain behavior of rats with osteoarthritis (OA). Forty-nine Wistar rats were allocated into seven groups; control (no MIA), MIA as a non-supplemental group with monosodium iodoacetate (MIA)-induced knee osteoarthritis, MIA + undenatured type II collagen (UCII) at 4 mg/kg BW, MIA + Niacinamide at 40 mg/kg BW (NA40), MIA + Niacinamide at 200 mg/kg BW (NA200), MIA + UCII + NA40 and MIA + UCII + NA200. Serum IL‐1β, IL‐6, TNF-α, COMP, and CRP increased in rats with OA and decreased in UCII and NA groups (p < 0.05). Rats with osteoarthritis had greater serum MDA and knee joint MMP-3, NF-κB, and TGβ protein levels and decreased in treated groups with UCII and NA (p < 0.05). The rats with OA also bore elevated joint diameters with joint pain behavior measured as decreased the stride lengths, the paw areas, and the paw widths, and increased the Kellgren-Lawrence and the Mankin scores (p < 0.05) and decreased in UCII treated groups. These results suggest the combinations with the UCII + NA supplementation as being most effective and reduce the inflammation responses for most OA symptoms in rats.Kazim SahinOsman KucukCemal OrhanMehmet TuzcuAli Said DurmusIbrahim Hanifi OzercanNurhan SahinVijaya JuturuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazim Sahin Osman Kucuk Cemal Orhan Mehmet Tuzcu Ali Said Durmus Ibrahim Hanifi Ozercan Nurhan Sahin Vijaya Juturu Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
description	Abstract The current work aimed to examine the properties of oral supplementation of niacinamide and undenatured type II collagen (UCII) on the inflammation and joint pain behavior of rats with osteoarthritis (OA). Forty-nine Wistar rats were allocated into seven groups; control (no MIA), MIA as a non-supplemental group with monosodium iodoacetate (MIA)-induced knee osteoarthritis, MIA + undenatured type II collagen (UCII) at 4 mg/kg BW, MIA + Niacinamide at 40 mg/kg BW (NA40), MIA + Niacinamide at 200 mg/kg BW (NA200), MIA + UCII + NA40 and MIA + UCII + NA200. Serum IL‐1β, IL‐6, TNF-α, COMP, and CRP increased in rats with OA and decreased in UCII and NA groups (p < 0.05). Rats with osteoarthritis had greater serum MDA and knee joint MMP-3, NF-κB, and TGβ protein levels and decreased in treated groups with UCII and NA (p < 0.05). The rats with OA also bore elevated joint diameters with joint pain behavior measured as decreased the stride lengths, the paw areas, and the paw widths, and increased the Kellgren-Lawrence and the Mankin scores (p < 0.05) and decreased in UCII treated groups. These results suggest the combinations with the UCII + NA supplementation as being most effective and reduce the inflammation responses for most OA symptoms in rats.
format	article
author	Kazim Sahin Osman Kucuk Cemal Orhan Mehmet Tuzcu Ali Said Durmus Ibrahim Hanifi Ozercan Nurhan Sahin Vijaya Juturu
author_facet	Kazim Sahin Osman Kucuk Cemal Orhan Mehmet Tuzcu Ali Said Durmus Ibrahim Hanifi Ozercan Nurhan Sahin Vijaya Juturu
author_sort	Kazim Sahin
title	Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
title_short	Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
title_full	Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
title_fullStr	Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
title_full_unstemmed	Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
title_sort	niacinamide and undenatured type ii collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56b4fa05c2f449798b6cc6935d54c1af
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Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis

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