Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the authors provide the structure of nsp10-nsp16 with the panMTase inhibitor sinefungin and report that the development of MTase inhibitor ther...

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Autores principales:	Petra Krafcikova, Jan Silhan, Radim Nencka, Evzen Boura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56b68d24fa284e44a0da700bbd0bc2ff
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spelling	oai:doaj.org-article:56b68d24fa284e44a0da700bbd0bc2ff2021-12-02T16:26:26ZStructural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin10.1038/s41467-020-17495-92041-1723https://doaj.org/article/56b68d24fa284e44a0da700bbd0bc2ff2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17495-9https://doaj.org/toc/2041-1723SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the authors provide the structure of nsp10-nsp16 with the panMTase inhibitor sinefungin and report that the development of MTase inhibitor therapies that target multiple coronoaviruses is feasible.Petra KrafcikovaJan SilhanRadim NenckaEvzen BouraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Petra Krafcikova Jan Silhan Radim Nencka Evzen Boura Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
description	SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the authors provide the structure of nsp10-nsp16 with the panMTase inhibitor sinefungin and report that the development of MTase inhibitor therapies that target multiple coronoaviruses is feasible.
format	article
author	Petra Krafcikova Jan Silhan Radim Nencka Evzen Boura
author_facet	Petra Krafcikova Jan Silhan Radim Nencka Evzen Boura
author_sort	Petra Krafcikova
title	Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
title_short	Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
title_full	Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
title_fullStr	Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
title_full_unstemmed	Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
title_sort	structural analysis of the sars-cov-2 methyltransferase complex involved in rna cap creation bound to sinefungin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/56b68d24fa284e44a0da700bbd0bc2ff
work_keys_str_mv	AT petrakrafcikova structuralanalysisofthesarscov2methyltransferasecomplexinvolvedinrnacapcreationboundtosinefungin AT jansilhan structuralanalysisofthesarscov2methyltransferasecomplexinvolvedinrnacapcreationboundtosinefungin AT radimnencka structuralanalysisofthesarscov2methyltransferasecomplexinvolvedinrnacapcreationboundtosinefungin AT evzenboura structuralanalysisofthesarscov2methyltransferasecomplexinvolvedinrnacapcreationboundtosinefungin
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Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

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