Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

Mitochondrial fission and fusion are important mechanisms to maintain mitochondrial function. Here, the authors report that middle-aged flies have more elongated, or ‘hyper-fused’ mitochondria, and show that induction of mitochondrial fission in midlife, but not in early life, extends the health and...

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Auteurs principaux:	Anil Rana, Matheus P. Oliveira, Andy V. Khamoui, Ricardo Aparicio, Michael Rera, Harry B. Rossiter, David W. Walker
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/56b69cd7b02648e89c37e7fc3efa2845
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id	oai:doaj.org-article:56b69cd7b02648e89c37e7fc3efa2845
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spelling	oai:doaj.org-article:56b69cd7b02648e89c37e7fc3efa28452021-12-02T17:06:31ZPromoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster10.1038/s41467-017-00525-42041-1723https://doaj.org/article/56b69cd7b02648e89c37e7fc3efa28452017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00525-4https://doaj.org/toc/2041-1723Mitochondrial fission and fusion are important mechanisms to maintain mitochondrial function. Here, the authors report that middle-aged flies have more elongated, or ‘hyper-fused’ mitochondria, and show that induction of mitochondrial fission in midlife, but not in early life, extends the health and life of flies.Anil RanaMatheus P. OliveiraAndy V. KhamouiRicardo AparicioMichael ReraHarry B. RossiterDavid W. WalkerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anil Rana Matheus P. Oliveira Andy V. Khamoui Ricardo Aparicio Michael Rera Harry B. Rossiter David W. Walker Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
description	Mitochondrial fission and fusion are important mechanisms to maintain mitochondrial function. Here, the authors report that middle-aged flies have more elongated, or ‘hyper-fused’ mitochondria, and show that induction of mitochondrial fission in midlife, but not in early life, extends the health and life of flies.
format	article
author	Anil Rana Matheus P. Oliveira Andy V. Khamoui Ricardo Aparicio Michael Rera Harry B. Rossiter David W. Walker
author_facet	Anil Rana Matheus P. Oliveira Andy V. Khamoui Ricardo Aparicio Michael Rera Harry B. Rossiter David W. Walker
author_sort	Anil Rana
title	Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
title_short	Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
title_full	Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
title_fullStr	Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
title_full_unstemmed	Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
title_sort	promoting drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of drosophila melanogaster
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/56b69cd7b02648e89c37e7fc3efa2845
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Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

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