Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Abstract Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The present work reports the design and synthesis of a hybrid of the precursors of rifampicin and clofazimine, which led to the discovery of a novel Rifaphenazine (RPZ) molecule with potent a...

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Autores principales: Pasupathy Saravanan, V. N. Azger Dusthackeer, R. S. Rajmani, B. Mahizhaveni, Christy R. Nirmal, Sam Ebenezer Rajadas, Neerupma Bhardwaj, C. Ponnuraja, Adhin Bhaskar, A. K. Hemanthkumar, Geetha Ramachandran, Srikanth P. Tripathy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/56b9adfff36d4fa4b354549045157315
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