VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons.
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Nature Portfolio
2016
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oai:doaj.org-article:56b9ffe539cc4faf8078eb7f130ffa072021-12-02T15:35:02ZVCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation10.1038/ncomms110202041-1723https://doaj.org/article/56b9ffe539cc4faf8078eb7f130ffa072016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11020https://doaj.org/toc/2041-1723Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons.Yu-Tzu ShihYi-Ping HsuehNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
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Science Q Yu-Tzu Shih Yi-Ping Hsueh VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
description |
Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons. |
format |
article |
author |
Yu-Tzu Shih Yi-Ping Hsueh |
author_facet |
Yu-Tzu Shih Yi-Ping Hsueh |
author_sort |
Yu-Tzu Shih |
title |
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
title_short |
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
title_full |
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
title_fullStr |
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
title_full_unstemmed |
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
title_sort |
vcp and atl1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/56b9ffe539cc4faf8078eb7f130ffa07 |
work_keys_str_mv |
AT yutzushih vcpandatl1regulateendoplasmicreticulumandproteinsynthesisfordendriticspineformation AT yipinghsueh vcpandatl1regulateendoplasmicreticulumandproteinsynthesisfordendriticspineformation |
_version_ |
1718386655772016640 |