VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation

Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons.

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Autores principales: Yu-Tzu Shih, Yi-Ping Hsueh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/56b9ffe539cc4faf8078eb7f130ffa07
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spelling oai:doaj.org-article:56b9ffe539cc4faf8078eb7f130ffa072021-12-02T15:35:02ZVCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation10.1038/ncomms110202041-1723https://doaj.org/article/56b9ffe539cc4faf8078eb7f130ffa072016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11020https://doaj.org/toc/2041-1723Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons.Yu-Tzu ShihYi-Ping HsuehNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu-Tzu Shih
Yi-Ping Hsueh
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
description Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons.
format article
author Yu-Tzu Shih
Yi-Ping Hsueh
author_facet Yu-Tzu Shih
Yi-Ping Hsueh
author_sort Yu-Tzu Shih
title VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
title_short VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
title_full VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
title_fullStr VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
title_full_unstemmed VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
title_sort vcp and atl1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/56b9ffe539cc4faf8078eb7f130ffa07
work_keys_str_mv AT yutzushih vcpandatl1regulateendoplasmicreticulumandproteinsynthesisfordendriticspineformation
AT yipinghsueh vcpandatl1regulateendoplasmicreticulumandproteinsynthesisfordendriticspineformation
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