An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins

The spindle matrix proteins, including Chro, are known to regulate mitotic spindle assembly in the cytoplasm. Here the authors show that in Drosophila larval brain, Chro promotes neural stem cell (NSC) reactivation and prevents activated NSCs from entering quiescence, and that Chro carries out such...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Song Li, Chwee Tat Koe, Su Ting Tay, Angie Lay Keng Tan, Shenli Zhang, Yingjie Zhang, Patrick Tan, Wing-Kin Sung, Hongyan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56bb01d0b76b4e4b9c7eb4cb6ffab76a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:56bb01d0b76b4e4b9c7eb4cb6ffab76a
record_format	dspace
spelling	oai:doaj.org-article:56bb01d0b76b4e4b9c7eb4cb6ffab76a2021-12-02T13:24:23ZAn intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins10.1038/s41467-017-00172-92041-1723https://doaj.org/article/56bb01d0b76b4e4b9c7eb4cb6ffab76a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00172-9https://doaj.org/toc/2041-1723The spindle matrix proteins, including Chro, are known to regulate mitotic spindle assembly in the cytoplasm. Here the authors show that in Drosophila larval brain, Chro promotes neural stem cell (NSC) reactivation and prevents activated NSCs from entering quiescence, and that Chro carries out such a role by regulating the expression of key transcription factors in the nucleus.Song LiChwee Tat KoeSu Ting TayAngie Lay Keng TanShenli ZhangYingjie ZhangPatrick TanWing-Kin SungHongyan WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Li Chwee Tat Koe Su Ting Tay Angie Lay Keng Tan Shenli Zhang Yingjie Zhang Patrick Tan Wing-Kin Sung Hongyan Wang An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
description	The spindle matrix proteins, including Chro, are known to regulate mitotic spindle assembly in the cytoplasm. Here the authors show that in Drosophila larval brain, Chro promotes neural stem cell (NSC) reactivation and prevents activated NSCs from entering quiescence, and that Chro carries out such a role by regulating the expression of key transcription factors in the nucleus.
format	article
author	Song Li Chwee Tat Koe Su Ting Tay Angie Lay Keng Tan Shenli Zhang Yingjie Zhang Patrick Tan Wing-Kin Sung Hongyan Wang
author_facet	Song Li Chwee Tat Koe Su Ting Tay Angie Lay Keng Tan Shenli Zhang Yingjie Zhang Patrick Tan Wing-Kin Sung Hongyan Wang
author_sort	Song Li
title	An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
title_short	An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
title_full	An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
title_fullStr	An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
title_full_unstemmed	An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
title_sort	intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/56bb01d0b76b4e4b9c7eb4cb6ffab76a
work_keys_str_mv	AT songli anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT chweetatkoe anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT sutingtay anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT angielaykengtan anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT shenlizhang anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT yingjiezhang anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT patricktan anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT wingkinsung anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT hongyanwang anintrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT songli intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT chweetatkoe intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT sutingtay intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT angielaykengtan intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT shenlizhang intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT yingjiezhang intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT patricktan intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT wingkinsung intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins AT hongyanwang intrinsicmechanismcontrolsreactivationofneuralstemcellsbyspindlematrixproteins
_version_	1718393094558187520

An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins

Ejemplares similares