Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia

Central centrifugal cicatricial alopecia (CCCA) is associated with increased expression of genes implicated in fibroproliferative disorders and a higher prevalence of uterine leiomyomas (ULs) among affected individuals. We sought to examine the effect of UL status on the gene expression profile of t...

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Autores principales:	Taylor A. Jamerson, C. Conover Talbot, Jr., Yemisi Dina, Crystal Aguh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/56bc6962dfbc40df80706664273be8ae
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spelling	oai:doaj.org-article:56bc6962dfbc40df80706664273be8ae2021-11-12T04:49:36ZPresence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia2667-026710.1016/j.xjidi.2021.100060https://doaj.org/article/56bc6962dfbc40df80706664273be8ae2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667026721000618https://doaj.org/toc/2667-0267Central centrifugal cicatricial alopecia (CCCA) is associated with increased expression of genes implicated in fibroproliferative disorders and a higher prevalence of uterine leiomyomas (ULs) among affected individuals. We sought to examine the effect of UL status on the gene expression profile of the lesional scalp in patients with CCCA. Scalp biopsy was obtained from 16 patients with a confirmed diagnosis of CCCA between 2017 and 2020. Microarray analysis was used to identify differential gene expression between patients with CCCA with a history of UL and those without the history. Of more than 20,000 genes analyzed, 23 of 25 genes with the highest expression in patients with CCCA with UL held no statistical significance. No genes previously implicated in fibroproliferative disorders were found among the upregulated transcripts. Of all genes analyzed, only eight upregulated genes and zero downregulated genes had a fold change in expression >2 in patients with CCCA with UL compared with those in patients with CCCA without UL. Our findings highlight similar gene expression patterns in the lesional scalp of patients with CCCA with and without a history of UL. This analysis is key in highlighting no evidence of causational or linked mechanobiology that accounts for the increased prevalence of UL seen in patients with CCCA that previous studies have not addressed.Taylor A. JamersonC. Conover Talbot, Jr.Yemisi DinaCrystal AguhElsevierarticleDermatologyRL1-803ENJID Innovations, Vol 2, Iss 1, Pp 100060- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Taylor A. Jamerson C. Conover Talbot, Jr. Yemisi Dina Crystal Aguh Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia
description	Central centrifugal cicatricial alopecia (CCCA) is associated with increased expression of genes implicated in fibroproliferative disorders and a higher prevalence of uterine leiomyomas (ULs) among affected individuals. We sought to examine the effect of UL status on the gene expression profile of the lesional scalp in patients with CCCA. Scalp biopsy was obtained from 16 patients with a confirmed diagnosis of CCCA between 2017 and 2020. Microarray analysis was used to identify differential gene expression between patients with CCCA with a history of UL and those without the history. Of more than 20,000 genes analyzed, 23 of 25 genes with the highest expression in patients with CCCA with UL held no statistical significance. No genes previously implicated in fibroproliferative disorders were found among the upregulated transcripts. Of all genes analyzed, only eight upregulated genes and zero downregulated genes had a fold change in expression >2 in patients with CCCA with UL compared with those in patients with CCCA without UL. Our findings highlight similar gene expression patterns in the lesional scalp of patients with CCCA with and without a history of UL. This analysis is key in highlighting no evidence of causational or linked mechanobiology that accounts for the increased prevalence of UL seen in patients with CCCA that previous studies have not addressed.
format	article
author	Taylor A. Jamerson C. Conover Talbot, Jr. Yemisi Dina Crystal Aguh
author_facet	Taylor A. Jamerson C. Conover Talbot, Jr. Yemisi Dina Crystal Aguh
author_sort	Taylor A. Jamerson
title	Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia
title_short	Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia
title_full	Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia
title_fullStr	Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia
title_full_unstemmed	Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia
title_sort	presence of uterine leiomyomas has no significant impact on gene expression profile in the scalp of patients with central centrifugal cicatricial alopecia
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/56bc6962dfbc40df80706664273be8ae
work_keys_str_mv	AT taylorajamerson presenceofuterineleiomyomashasnosignificantimpactongeneexpressionprofileinthescalpofpatientswithcentralcentrifugalcicatricialalopecia AT cconovertalbotjr presenceofuterineleiomyomashasnosignificantimpactongeneexpressionprofileinthescalpofpatientswithcentralcentrifugalcicatricialalopecia AT yemisidina presenceofuterineleiomyomashasnosignificantimpactongeneexpressionprofileinthescalpofpatientswithcentralcentrifugalcicatricialalopecia AT crystalaguh presenceofuterineleiomyomashasnosignificantimpactongeneexpressionprofileinthescalpofpatientswithcentralcentrifugalcicatricialalopecia
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Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia

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