COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN

BACKGROUND AND OBJECTIVE: According to the importance of thyroid hormone on growth, especially bone mineral density (BMD), in this study, long term effects of levothyroxine replacement therapy on BMD in hypothyroid children in comparison with normal children was evaluated. METHODS: In this historica...

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Autores principales:	P Eshraghi, Z Karamizadeh, A Amirhakimi, GH.H Amirhakimi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	bone mineral density levothyroxine hypothyroidism children Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/56bead01a45d4c818a54f5f5333f2db9
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spelling	oai:doaj.org-article:56bead01a45d4c818a54f5f5333f2db92021-11-10T09:07:19ZCOMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN1561-41072251-7170https://doaj.org/article/56bead01a45d4c818a54f5f5333f2db92008-04-01T00:00:00Zhttp://jbums.org/article-1-2480-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: According to the importance of thyroid hormone on growth, especially bone mineral density (BMD), in this study, long term effects of levothyroxine replacement therapy on BMD in hypothyroid children in comparison with normal children was evaluated. METHODS: In this historical cohort study, long term effects of levothyroxine on BMD and biochemical markers in acquired and congenital hypothyroid children versus compared group were evaluated. Twenty three children with congenital and acquired hypothyroidism who received levothyroxine replacement therapy regularly for at least 1 year and followed up once every 3 months were studied. In control 30 prepubertal children preferably from patients family were selected. FINDINGS: Mean age in compared group was 8.8±4.3 and in case group was 10.4±3.3 years and average duration of treatment was 7.3 years. Results of spine and femur BMD in patients was 0.73±0.26 and 0.70±0.17, respectively. Also in control, BMD of spine and femur was 0.77±0.07 and 0.57±0.28. So, the difference between two groups was not significant. CONCLUSION: Our results showed that levothyroxine replacement therapy do not decrease BMD in comparison with compared group. So, long term levothyroxine replacement therapy is not detrimental to the skeletal mineralization and BMD of patients with normal TSH will be as like as euthyroid healthy children.P Eshraghi,Z KaramizadehA AmirhakimiGH.H AmirhakimiBabol University of Medical Sciencesarticlebone mineral densitylevothyroxinehypothyroidismchildrenMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 1, Pp 28-32 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	bone mineral density levothyroxine hypothyroidism children Medicine R Medicine (General) R5-920
spellingShingle	bone mineral density levothyroxine hypothyroidism children Medicine R Medicine (General) R5-920 P Eshraghi, Z Karamizadeh A Amirhakimi GH.H Amirhakimi COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN
description	BACKGROUND AND OBJECTIVE: According to the importance of thyroid hormone on growth, especially bone mineral density (BMD), in this study, long term effects of levothyroxine replacement therapy on BMD in hypothyroid children in comparison with normal children was evaluated. METHODS: In this historical cohort study, long term effects of levothyroxine on BMD and biochemical markers in acquired and congenital hypothyroid children versus compared group were evaluated. Twenty three children with congenital and acquired hypothyroidism who received levothyroxine replacement therapy regularly for at least 1 year and followed up once every 3 months were studied. In control 30 prepubertal children preferably from patients family were selected. FINDINGS: Mean age in compared group was 8.8±4.3 and in case group was 10.4±3.3 years and average duration of treatment was 7.3 years. Results of spine and femur BMD in patients was 0.73±0.26 and 0.70±0.17, respectively. Also in control, BMD of spine and femur was 0.77±0.07 and 0.57±0.28. So, the difference between two groups was not significant. CONCLUSION: Our results showed that levothyroxine replacement therapy do not decrease BMD in comparison with compared group. So, long term levothyroxine replacement therapy is not detrimental to the skeletal mineralization and BMD of patients with normal TSH will be as like as euthyroid healthy children.
format	article
author	P Eshraghi, Z Karamizadeh A Amirhakimi GH.H Amirhakimi
author_facet	P Eshraghi, Z Karamizadeh A Amirhakimi GH.H Amirhakimi
author_sort	P Eshraghi,
title	COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN
title_short	COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN
title_full	COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN
title_fullStr	COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN
title_full_unstemmed	COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN
title_sort	comparison of bone mineral density in hypothyroid children under levothyroxine replacement therapy with normal children
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/56bead01a45d4c818a54f5f5333f2db9
work_keys_str_mv	AT peshraghi comparisonofbonemineraldensityinhypothyroidchildrenunderlevothyroxinereplacementtherapywithnormalchildren AT zkaramizadeh comparisonofbonemineraldensityinhypothyroidchildrenunderlevothyroxinereplacementtherapywithnormalchildren AT aamirhakimi comparisonofbonemineraldensityinhypothyroidchildrenunderlevothyroxinereplacementtherapywithnormalchildren AT ghhamirhakimi comparisonofbonemineraldensityinhypothyroidchildrenunderlevothyroxinereplacementtherapywithnormalchildren
_version_	1718440283934294016

COMPARISON OF BONE MINERAL DENSITY IN HYPOTHYROID CHILDREN UNDER LEVOTHYROXINE REPLACEMENT THERAPY WITH NORMAL CHILDREN

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