Association between body water status and acute mountain sickness.

<h4>Purpose</h4>The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults.<h4>Methods</h4>Forty-three healthy participants (26 males and 17 females, age: 26 ± 6 yr, height: 174 ± 9 cm, weight: 68 ±...

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Autores principales:	Hannes Gatterer, Maria Wille, Martin Faulhaber, Henry Lukaski, Andreas Melmer, Christoph Ebenbichler, Martin Burtscher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56c278e5d3b34ce49caabdcfaa9fbf9b
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spelling	oai:doaj.org-article:56c278e5d3b34ce49caabdcfaa9fbf9b2021-11-18T08:58:07ZAssociation between body water status and acute mountain sickness.1932-620310.1371/journal.pone.0073185https://doaj.org/article/56c278e5d3b34ce49caabdcfaa9fbf9b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24013267/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults.<h4>Methods</h4>Forty-three healthy participants (26 males and 17 females, age: 26 ± 6 yr, height: 174 ± 9 cm, weight: 68 ± 12 kg) were passively exposed at a FiO2 of 12.6% (simulated altitude hypoxia of 4500 m, PiO2 = 83.9 mmHg) for 12-h. AMS severity was assessed using the Lake Louise Score (LLS). Food and drink intakes were consumed ad libitum and measured; all urine was collected. Before and after the 12-h exposure, body weight and plasma osmolality were measured and whole-body bioimpedance analysis was performed.<h4>Results</h4>The overall AMS incidence was 43% (38% males, 50% females). Participants who developed AMS showed lower fluid losses (3.0 ± 0.9 vs. 4.5 ± 2.0 ml/kg/h, p = 0.002), a higher fluid retention (1.9 ± 1.5 vs. 0.6 ± 0.8 ml/kg/h, p = 0.022), greater plasma osmolality decreases (-7 ± 7 vs. -2 ± 5 mOsm/kg, p = 0.028) and a larger plasma volume expansion (11 ± 10 vs. 1 ± 15%, p = 0.041) compared to participants not developing AMS. Net water balance (fluid intake--fluid loss) and the amount of fluid loss were strong predictors whether getting sick or not (Nagelkerkes r(2) = 0.532). The LLS score was related to net water balance (r = 0.358, p = 0.018), changes in plasma osmolality (r = -0.325, p = 0.033) and sodium concentration (r = -0.305, p = 0.047). Changes in the impedance vector length were related to weight changes (r = -0.550, p<0.001), fluid intake (r = -0.533, p<0.001) and net water balance (r = -0.590, p<0.001).<h4>Conclusions</h4>Participants developing AMS within 12 hours showed a positive net water balance due to low fluid loss. Thus measures to avoid excess fluid retention are likely to reduce AMS symptoms.Hannes GattererMaria WilleMartin FaulhaberHenry LukaskiAndreas MelmerChristoph EbenbichlerMartin BurtscherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e73185 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hannes Gatterer Maria Wille Martin Faulhaber Henry Lukaski Andreas Melmer Christoph Ebenbichler Martin Burtscher Association between body water status and acute mountain sickness.
description	<h4>Purpose</h4>The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults.<h4>Methods</h4>Forty-three healthy participants (26 males and 17 females, age: 26 ± 6 yr, height: 174 ± 9 cm, weight: 68 ± 12 kg) were passively exposed at a FiO2 of 12.6% (simulated altitude hypoxia of 4500 m, PiO2 = 83.9 mmHg) for 12-h. AMS severity was assessed using the Lake Louise Score (LLS). Food and drink intakes were consumed ad libitum and measured; all urine was collected. Before and after the 12-h exposure, body weight and plasma osmolality were measured and whole-body bioimpedance analysis was performed.<h4>Results</h4>The overall AMS incidence was 43% (38% males, 50% females). Participants who developed AMS showed lower fluid losses (3.0 ± 0.9 vs. 4.5 ± 2.0 ml/kg/h, p = 0.002), a higher fluid retention (1.9 ± 1.5 vs. 0.6 ± 0.8 ml/kg/h, p = 0.022), greater plasma osmolality decreases (-7 ± 7 vs. -2 ± 5 mOsm/kg, p = 0.028) and a larger plasma volume expansion (11 ± 10 vs. 1 ± 15%, p = 0.041) compared to participants not developing AMS. Net water balance (fluid intake--fluid loss) and the amount of fluid loss were strong predictors whether getting sick or not (Nagelkerkes r(2) = 0.532). The LLS score was related to net water balance (r = 0.358, p = 0.018), changes in plasma osmolality (r = -0.325, p = 0.033) and sodium concentration (r = -0.305, p = 0.047). Changes in the impedance vector length were related to weight changes (r = -0.550, p<0.001), fluid intake (r = -0.533, p<0.001) and net water balance (r = -0.590, p<0.001).<h4>Conclusions</h4>Participants developing AMS within 12 hours showed a positive net water balance due to low fluid loss. Thus measures to avoid excess fluid retention are likely to reduce AMS symptoms.
format	article
author	Hannes Gatterer Maria Wille Martin Faulhaber Henry Lukaski Andreas Melmer Christoph Ebenbichler Martin Burtscher
author_facet	Hannes Gatterer Maria Wille Martin Faulhaber Henry Lukaski Andreas Melmer Christoph Ebenbichler Martin Burtscher
author_sort	Hannes Gatterer
title	Association between body water status and acute mountain sickness.
title_short	Association between body water status and acute mountain sickness.
title_full	Association between body water status and acute mountain sickness.
title_fullStr	Association between body water status and acute mountain sickness.
title_full_unstemmed	Association between body water status and acute mountain sickness.
title_sort	association between body water status and acute mountain sickness.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/56c278e5d3b34ce49caabdcfaa9fbf9b
work_keys_str_mv	AT hannesgatterer associationbetweenbodywaterstatusandacutemountainsickness AT mariawille associationbetweenbodywaterstatusandacutemountainsickness AT martinfaulhaber associationbetweenbodywaterstatusandacutemountainsickness AT henrylukaski associationbetweenbodywaterstatusandacutemountainsickness AT andreasmelmer associationbetweenbodywaterstatusandacutemountainsickness AT christophebenbichler associationbetweenbodywaterstatusandacutemountainsickness AT martinburtscher associationbetweenbodywaterstatusandacutemountainsickness
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Association between body water status and acute mountain sickness.

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