Modern basal insulins: an ongoing story or the start of a new era?
Basal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment. Despite significant progress in understanding the physiology, chemistry, kinetics and action of insulin,...
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Endocrinology Research Centre
2015
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oai:doaj.org-article:56c4eb10926d4375bf48510fb0af4b632021-11-14T09:00:20ZModern basal insulins: an ongoing story or the start of a new era?2072-03512072-037810.14341/DM7693https://doaj.org/article/56c4eb10926d4375bf48510fb0af4b632015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7693https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Basal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment. Despite significant progress in understanding the physiology, chemistry, kinetics and action of insulin, currently available basal insulin products do not optimally mimic the endogenous profile of insulin. Although basal insulin analogues have some advantages over neutral protamine Hagedorn insulin in diabetes treatment, hypoglycaemia remains the main problem in the achievement of optimal glycaemic control in most patients with diabetes. These unmet clinical needs have stimulated the development of new basal insulin analogues with improved pharmacological profiles. This article reviews the specific characteristics of new long-acting insulin analogues to try and understand their benefits and limitations in the improvement of diabetes management and their possibilities in physiologic and safe insulin replacement.Ivan Ivanovich DedovEndocrinology Research Centrearticlediabetes mellitusinsulin therapybasal insulin analogues evolutiondegludecNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 5-11 (2015) |
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DOAJ |
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DOAJ |
| language |
EN RU |
| topic |
diabetes mellitus insulin therapy basal insulin analogues evolution degludec Nutritional diseases. Deficiency diseases RC620-627 |
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diabetes mellitus insulin therapy basal insulin analogues evolution degludec Nutritional diseases. Deficiency diseases RC620-627 Ivan Ivanovich Dedov Modern basal insulins: an ongoing story or the start of a new era? |
| description |
Basal insulin represents an essential tool in the treatment of both type 1 and type 2 diabetes mellitus. The development of insulin analogues has improved the possibilities of diabetes treatment. Despite significant progress in understanding the physiology, chemistry, kinetics and action of insulin, currently available basal insulin products do not optimally mimic the endogenous profile of insulin. Although basal insulin analogues have some advantages over neutral protamine Hagedorn insulin in diabetes treatment, hypoglycaemia remains the main problem in the achievement of optimal glycaemic control in most patients with diabetes. These unmet clinical needs have stimulated the development of new basal insulin analogues with improved pharmacological profiles. This article reviews the specific characteristics of new long-acting insulin analogues to try and understand their benefits and limitations in the improvement of diabetes management and their possibilities in physiologic and safe insulin replacement. |
| format |
article |
| author |
Ivan Ivanovich Dedov |
| author_facet |
Ivan Ivanovich Dedov |
| author_sort |
Ivan Ivanovich Dedov |
| title |
Modern basal insulins: an ongoing story or the start of a new era? |
| title_short |
Modern basal insulins: an ongoing story or the start of a new era? |
| title_full |
Modern basal insulins: an ongoing story or the start of a new era? |
| title_fullStr |
Modern basal insulins: an ongoing story or the start of a new era? |
| title_full_unstemmed |
Modern basal insulins: an ongoing story or the start of a new era? |
| title_sort |
modern basal insulins: an ongoing story or the start of a new era? |
| publisher |
Endocrinology Research Centre |
| publishDate |
2015 |
| url |
https://doaj.org/article/56c4eb10926d4375bf48510fb0af4b63 |
| work_keys_str_mv |
AT ivanivanovichdedov modernbasalinsulinsanongoingstoryorthestartofanewera |
| _version_ |
1718429528240422912 |