Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa

The number of sporadic and epidemic dengue fever cases have reportedly been increasing in recent years in some West African countries, such as Senegal and Mali. The first epidemic of laboratory-confirmed dengue occurred in Nouakchott, the capital city of Mauritania situated in the Saharan desert, in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Toscane Fourié, Ahmed El Bara, Audrey Dubot-Pérès, Gilda Grard, Sébastien Briolant, Leonardo K. Basco, Mohamed Ouldabdallahi Moukah, Isabelle Leparc-Goffart
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/56c5b0a7bf2144a593ad3662becc4311
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:56c5b0a7bf2144a593ad3662becc4311
record_format	dspace
spelling	oai:doaj.org-article:56c5b0a7bf2144a593ad3662becc43112021-11-11T09:25:06ZEmergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa1935-27271935-2735https://doaj.org/article/56c5b0a7bf2144a593ad3662becc43112021-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568173/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735The number of sporadic and epidemic dengue fever cases have reportedly been increasing in recent years in some West African countries, such as Senegal and Mali. The first epidemic of laboratory-confirmed dengue occurred in Nouakchott, the capital city of Mauritania situated in the Saharan desert, in 2014. On-site diagnosis of dengue fever was established using a rapid diagnostic test for dengue. In parallel, the presence of Aedes aegypti mosquitoes in the city was confirmed. The initial diagnosis was confirmed by RT-PCR, which showed that all samples from the 2014 dengue epidemic in Nouakchott were dengue virus serotype 2 (DENV-2). The whole genome or envelope protein gene of these strains, together with other DENV-2 strains obtained from travelers returning from West African countries to France between 2016 and 2019 (including two Mauritanian strains in 2017 and 2018), were sequenced. Phylogenetic analysis suggested a recent emergence of an epidemic strain from the cosmopolitan genotype belonging to West African cosmopolitan lineage II, which is genetically distinct from African sylvatic genotype. The origin of this DENV-2 lineage is still unknown, but our data seem to suggest a recent and rapid dispersion of the epidemic strain throughout the region. More complete genome sequences of West African DENV-2 are required for a better understanding of the dynamics of its circulation. Arboviral surveillance and outbreak forecasting are urgently needed in West Africa. Author summary In Africa, dengue viruses 1 to 4 are transmitted to primates by Aedes mosquitoes in a sylvatic cycle or an urban/epidemic cycle involving humans. Infection in humans may be asymptomatic or may range from mild flu-like illness to severe hemorrhagic fever. The dengue viruses have a pantropical distribution, mostly in urbanized areas where vectors have become well adapted. This report shows dengue can also emerge in desert areas, as seen for the first time in an outbreak in 2014 in Nouakchott, Mauritania, where climatic, environmental, and human behavioral changes favor the emergence of Aedes mosquitoes. Dengue virus 2 was found in multiple human samples collected during the outbreak. Genomic analysis of dengue virus 2 isolates from the Mauritanian outbreak and from infected travelers revealed the rapid emergence of a specific “West African epidemic strain” of the virus throughout West Africa during the last decade, which is distinct from other strains found elsewhere and from historical or sylvatic strains. More genomic data would help us understand the circulation of dengue virus in West Africa, to help forecast and mitigate outbreaks in this region.Toscane FouriéAhmed El BaraAudrey Dubot-PérèsGilda GrardSébastien BriolantLeonardo K. BascoMohamed Ouldabdallahi MoukahIsabelle Leparc-GoffartPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Toscane Fourié Ahmed El Bara Audrey Dubot-Pérès Gilda Grard Sébastien Briolant Leonardo K. Basco Mohamed Ouldabdallahi Moukah Isabelle Leparc-Goffart Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa
description	The number of sporadic and epidemic dengue fever cases have reportedly been increasing in recent years in some West African countries, such as Senegal and Mali. The first epidemic of laboratory-confirmed dengue occurred in Nouakchott, the capital city of Mauritania situated in the Saharan desert, in 2014. On-site diagnosis of dengue fever was established using a rapid diagnostic test for dengue. In parallel, the presence of Aedes aegypti mosquitoes in the city was confirmed. The initial diagnosis was confirmed by RT-PCR, which showed that all samples from the 2014 dengue epidemic in Nouakchott were dengue virus serotype 2 (DENV-2). The whole genome or envelope protein gene of these strains, together with other DENV-2 strains obtained from travelers returning from West African countries to France between 2016 and 2019 (including two Mauritanian strains in 2017 and 2018), were sequenced. Phylogenetic analysis suggested a recent emergence of an epidemic strain from the cosmopolitan genotype belonging to West African cosmopolitan lineage II, which is genetically distinct from African sylvatic genotype. The origin of this DENV-2 lineage is still unknown, but our data seem to suggest a recent and rapid dispersion of the epidemic strain throughout the region. More complete genome sequences of West African DENV-2 are required for a better understanding of the dynamics of its circulation. Arboviral surveillance and outbreak forecasting are urgently needed in West Africa. Author summary In Africa, dengue viruses 1 to 4 are transmitted to primates by Aedes mosquitoes in a sylvatic cycle or an urban/epidemic cycle involving humans. Infection in humans may be asymptomatic or may range from mild flu-like illness to severe hemorrhagic fever. The dengue viruses have a pantropical distribution, mostly in urbanized areas where vectors have become well adapted. This report shows dengue can also emerge in desert areas, as seen for the first time in an outbreak in 2014 in Nouakchott, Mauritania, where climatic, environmental, and human behavioral changes favor the emergence of Aedes mosquitoes. Dengue virus 2 was found in multiple human samples collected during the outbreak. Genomic analysis of dengue virus 2 isolates from the Mauritanian outbreak and from infected travelers revealed the rapid emergence of a specific “West African epidemic strain” of the virus throughout West Africa during the last decade, which is distinct from other strains found elsewhere and from historical or sylvatic strains. More genomic data would help us understand the circulation of dengue virus in West Africa, to help forecast and mitigate outbreaks in this region.
format	article
author	Toscane Fourié Ahmed El Bara Audrey Dubot-Pérès Gilda Grard Sébastien Briolant Leonardo K. Basco Mohamed Ouldabdallahi Moukah Isabelle Leparc-Goffart
author_facet	Toscane Fourié Ahmed El Bara Audrey Dubot-Pérès Gilda Grard Sébastien Briolant Leonardo K. Basco Mohamed Ouldabdallahi Moukah Isabelle Leparc-Goffart
author_sort	Toscane Fourié
title	Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa
title_short	Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa
title_full	Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa
title_fullStr	Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa
title_full_unstemmed	Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa
title_sort	emergence of dengue virus serotype 2 in mauritania and molecular characterization of its circulation in west africa
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/56c5b0a7bf2144a593ad3662becc4311
work_keys_str_mv	AT toscanefourie emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT ahmedelbara emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT audreydubotperes emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT gildagrard emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT sebastienbriolant emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT leonardokbasco emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT mohamedouldabdallahimoukah emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica AT isabelleleparcgoffart emergenceofdenguevirusserotype2inmauritaniaandmolecularcharacterizationofitscirculationinwestafrica
_version_	1718439216184033280

Emergence of dengue virus serotype 2 in Mauritania and molecular characterization of its circulation in West Africa

Ejemplares similares