Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

The ability of the fungal pathogen Candida albicans to undergo yeast-to-hypha transition is believed to be a key virulence factor. Here, Dunker et al. show that a filament-deficient strain is attenuated in a mouse model of intraperitoneal infection, but remains virulent in a mouse model of systemic...

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Autores principales:	Christine Dunker, Melanie Polke, Bianca Schulze-Richter, Katja Schubert, Sven Rudolphi, A. Elisabeth Gressler, Tony Pawlik, Juan P. Prada Salcedo, M. Joanna Niemiec, Silvia Slesiona-Künzel, Marc Swidergall, Ronny Martin, Thomas Dandekar, Ilse D. Jacobsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56c898d46b974e6fb75c3234ffc538fb
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spelling	oai:doaj.org-article:56c898d46b974e6fb75c3234ffc538fb2021-12-02T17:12:20ZRapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain10.1038/s41467-021-24095-82041-1723https://doaj.org/article/56c898d46b974e6fb75c3234ffc538fb2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24095-8https://doaj.org/toc/2041-1723The ability of the fungal pathogen Candida albicans to undergo yeast-to-hypha transition is believed to be a key virulence factor. Here, Dunker et al. show that a filament-deficient strain is attenuated in a mouse model of intraperitoneal infection, but remains virulent in a mouse model of systemic candidiasis.Christine DunkerMelanie PolkeBianca Schulze-RichterKatja SchubertSven RudolphiA. Elisabeth GresslerTony PawlikJuan P. Prada SalcedoM. Joanna NiemiecSilvia Slesiona-KünzelMarc SwidergallRonny MartinThomas DandekarIlse D. JacobsenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine Dunker Melanie Polke Bianca Schulze-Richter Katja Schubert Sven Rudolphi A. Elisabeth Gressler Tony Pawlik Juan P. Prada Salcedo M. Joanna Niemiec Silvia Slesiona-Künzel Marc Swidergall Ronny Martin Thomas Dandekar Ilse D. Jacobsen Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
description	The ability of the fungal pathogen Candida albicans to undergo yeast-to-hypha transition is believed to be a key virulence factor. Here, Dunker et al. show that a filament-deficient strain is attenuated in a mouse model of intraperitoneal infection, but remains virulent in a mouse model of systemic candidiasis.
format	article
author	Christine Dunker Melanie Polke Bianca Schulze-Richter Katja Schubert Sven Rudolphi A. Elisabeth Gressler Tony Pawlik Juan P. Prada Salcedo M. Joanna Niemiec Silvia Slesiona-Künzel Marc Swidergall Ronny Martin Thomas Dandekar Ilse D. Jacobsen
author_facet	Christine Dunker Melanie Polke Bianca Schulze-Richter Katja Schubert Sven Rudolphi A. Elisabeth Gressler Tony Pawlik Juan P. Prada Salcedo M. Joanna Niemiec Silvia Slesiona-Künzel Marc Swidergall Ronny Martin Thomas Dandekar Ilse D. Jacobsen
author_sort	Christine Dunker
title	Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
title_short	Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
title_full	Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
title_fullStr	Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
title_full_unstemmed	Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
title_sort	rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient candida albicans strain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56c898d46b974e6fb75c3234ffc538fb
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Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

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