Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.

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Auteurs principaux: Shin-ichiro Honda, Kazuki Sato, Naoya Totsuka, Satoshi Fujiyama, Manabu Fujimoto, Kensuke Miyake, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Kazuko Shibuya, Akira Shibuya
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
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Accès en ligne:https://doaj.org/article/56c8baf3ce2c4f159fbd3742c478ed1d
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Résumé:Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.

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