Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.

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Autores principales:	Shin-ichiro Honda, Kazuki Sato, Naoya Totsuka, Satoshi Fujiyama, Manabu Fujimoto, Kensuke Miyake, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Kazuko Shibuya, Akira Shibuya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56c8baf3ce2c4f159fbd3742c478ed1d
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spelling	oai:doaj.org-article:56c8baf3ce2c4f159fbd3742c478ed1d2021-12-02T15:35:00ZMarginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling10.1038/ncomms114982041-1723https://doaj.org/article/56c8baf3ce2c4f159fbd3742c478ed1d2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11498https://doaj.org/toc/2041-1723Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.Shin-ichiro HondaKazuki SatoNaoya TotsukaSatoshi FujiyamaManabu FujimotoKensuke MiyakeChigusa Nakahashi-OdaSatoko Tahara-HanaokaKazuko ShibuyaAkira ShibuyaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shin-ichiro Honda Kazuki Sato Naoya Totsuka Satoshi Fujiyama Manabu Fujimoto Kensuke Miyake Chigusa Nakahashi-Oda Satoko Tahara-Hanaoka Kazuko Shibuya Akira Shibuya Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling
description	Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.
format	article
author	Shin-ichiro Honda Kazuki Sato Naoya Totsuka Satoshi Fujiyama Manabu Fujimoto Kensuke Miyake Chigusa Nakahashi-Oda Satoko Tahara-Hanaoka Kazuko Shibuya Akira Shibuya
author_facet	Shin-ichiro Honda Kazuki Sato Naoya Totsuka Satoshi Fujiyama Manabu Fujimoto Kensuke Miyake Chigusa Nakahashi-Oda Satoko Tahara-Hanaoka Kazuko Shibuya Akira Shibuya
author_sort	Shin-ichiro Honda
title	Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling
title_short	Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling
title_full	Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling
title_fullStr	Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling
title_full_unstemmed	Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling
title_sort	marginal zone b cells exacerbate endotoxic shock via interleukin-6 secretion induced by fcα/μr-coupled tlr4 signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/56c8baf3ce2c4f159fbd3742c478ed1d
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Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

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