Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins

Cysteine side chains are reactive sites of protein synthesis and modification. Here, the authors show that tuning palladium chemoselectivity allows for selective removal of several cysteine protection groups, and use their method to synthesize challenging protein analogues.

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Auteurs principaux:	Muhammad Jbara, Shay Laps, Michael Morgan, Guy Kamnesky, Guy Mann, Cynthia Wolberger, Ashraf Brik
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/56cd1cea37cd4f67b98746267de30aab
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spelling	oai:doaj.org-article:56cd1cea37cd4f67b98746267de30aab2021-12-02T16:49:35ZPalladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins10.1038/s41467-018-05628-02041-1723https://doaj.org/article/56cd1cea37cd4f67b98746267de30aab2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05628-0https://doaj.org/toc/2041-1723Cysteine side chains are reactive sites of protein synthesis and modification. Here, the authors show that tuning palladium chemoselectivity allows for selective removal of several cysteine protection groups, and use their method to synthesize challenging protein analogues.Muhammad JbaraShay LapsMichael MorganGuy KamneskyGuy MannCynthia WolbergerAshraf BrikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muhammad Jbara Shay Laps Michael Morgan Guy Kamnesky Guy Mann Cynthia Wolberger Ashraf Brik Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
description	Cysteine side chains are reactive sites of protein synthesis and modification. Here, the authors show that tuning palladium chemoselectivity allows for selective removal of several cysteine protection groups, and use their method to synthesize challenging protein analogues.
format	article
author	Muhammad Jbara Shay Laps Michael Morgan Guy Kamnesky Guy Mann Cynthia Wolberger Ashraf Brik
author_facet	Muhammad Jbara Shay Laps Michael Morgan Guy Kamnesky Guy Mann Cynthia Wolberger Ashraf Brik
author_sort	Muhammad Jbara
title	Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
title_short	Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
title_full	Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
title_fullStr	Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
title_full_unstemmed	Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
title_sort	palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/56cd1cea37cd4f67b98746267de30aab
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Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins

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