Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J

Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum alkaloid.

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Detalles Bibliográficos
Autores principales: Lian-Dong Guo, Yan Zhang, Jingping Hu, Chengqing Ning, Heyifei Fu, Yuye Chen, Jing Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/56d24c15a8254f91bc01a6357360c039
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Sumario:Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum alkaloid.