WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

During autophagy, AMPK and mTOR associate with ULK1 and regulate phosphatidylinositol 3-phosphate (PtdIns3P) production that mediates autophagosome formation via WIPI proteins. Here the authors show WIPI3 and WIPI4 have a scaffolding function upstream of PtdIns3P production and have a role in the Pt...

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Autores principales:	Daniela Bakula, Amelie J. Müller, Theresia Zuleger, Zsuzsanna Takacs, Mirita Franz-Wachtel, Ann-Katrin Thost, Daniel Brigger, Mario P. Tschan, Tancred Frickey, Horst Robenek, Boris Macek, Tassula Proikas-Cezanne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56d33a8705964370b0a1710e530dcc35
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spelling	oai:doaj.org-article:56d33a8705964370b0a1710e530dcc352021-12-02T17:06:17ZWIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy10.1038/ncomms156372041-1723https://doaj.org/article/56d33a8705964370b0a1710e530dcc352017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15637https://doaj.org/toc/2041-1723During autophagy, AMPK and mTOR associate with ULK1 and regulate phosphatidylinositol 3-phosphate (PtdIns3P) production that mediates autophagosome formation via WIPI proteins. Here the authors show WIPI3 and WIPI4 have a scaffolding function upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes.Daniela BakulaAmelie J. MüllerTheresia ZulegerZsuzsanna TakacsMirita Franz-WachtelAnn-Katrin ThostDaniel BriggerMario P. TschanTancred FrickeyHorst RobenekBoris MacekTassula Proikas-CezanneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Bakula Amelie J. Müller Theresia Zuleger Zsuzsanna Takacs Mirita Franz-Wachtel Ann-Katrin Thost Daniel Brigger Mario P. Tschan Tancred Frickey Horst Robenek Boris Macek Tassula Proikas-Cezanne WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
description	During autophagy, AMPK and mTOR associate with ULK1 and regulate phosphatidylinositol 3-phosphate (PtdIns3P) production that mediates autophagosome formation via WIPI proteins. Here the authors show WIPI3 and WIPI4 have a scaffolding function upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes.
format	article
author	Daniela Bakula Amelie J. Müller Theresia Zuleger Zsuzsanna Takacs Mirita Franz-Wachtel Ann-Katrin Thost Daniel Brigger Mario P. Tschan Tancred Frickey Horst Robenek Boris Macek Tassula Proikas-Cezanne
author_facet	Daniela Bakula Amelie J. Müller Theresia Zuleger Zsuzsanna Takacs Mirita Franz-Wachtel Ann-Katrin Thost Daniel Brigger Mario P. Tschan Tancred Frickey Horst Robenek Boris Macek Tassula Proikas-Cezanne
author_sort	Daniela Bakula
title	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
title_short	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
title_full	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
title_fullStr	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
title_full_unstemmed	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
title_sort	wipi3 and wipi4 β-propellers are scaffolds for lkb1-ampk-tsc signalling circuits in the control of autophagy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/56d33a8705964370b0a1710e530dcc35
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WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

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