STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a proinflammatory switch via an effect on mitochondrial...

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Autores principales:	Jesse J. Balic, Hassan Albargy, Kevin Luu, Francis J. Kirby, W. Samantha N. Jayasekara, Finbar Mansell, Daniel J. Garama, Dominic De Nardo, Nikola Baschuk, Cynthia Louis, Fiachra Humphries, Katherine Fitzgerald, Eicke Latz, Daniel J. Gough, Ashley Mansell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e
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spelling	oai:doaj.org-article:56d3ddfe137f4fb1a1f4f01e629a3c2e2021-12-02T16:24:53ZSTAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression10.1038/s41467-020-17669-52041-1723https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17669-5https://doaj.org/toc/2041-1723TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a proinflammatory switch via an effect on mitochondrial metabolism.Jesse J. BalicHassan AlbargyKevin LuuFrancis J. KirbyW. Samantha N. JayasekaraFinbar MansellDaniel J. GaramaDominic De NardoNikola BaschukCynthia LouisFiachra HumphriesKatherine FitzgeraldEicke LatzDaniel J. GoughAshley MansellNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jesse J. Balic Hassan Albargy Kevin Luu Francis J. Kirby W. Samantha N. Jayasekara Finbar Mansell Daniel J. Garama Dominic De Nardo Nikola Baschuk Cynthia Louis Fiachra Humphries Katherine Fitzgerald Eicke Latz Daniel J. Gough Ashley Mansell STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
description	TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a proinflammatory switch via an effect on mitochondrial metabolism.
format	article
author	Jesse J. Balic Hassan Albargy Kevin Luu Francis J. Kirby W. Samantha N. Jayasekara Finbar Mansell Daniel J. Garama Dominic De Nardo Nikola Baschuk Cynthia Louis Fiachra Humphries Katherine Fitzgerald Eicke Latz Daniel J. Gough Ashley Mansell
author_facet	Jesse J. Balic Hassan Albargy Kevin Luu Francis J. Kirby W. Samantha N. Jayasekara Finbar Mansell Daniel J. Garama Dominic De Nardo Nikola Baschuk Cynthia Louis Fiachra Humphries Katherine Fitzgerald Eicke Latz Daniel J. Gough Ashley Mansell
author_sort	Jesse J. Balic
title	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
title_short	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
title_full	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
title_fullStr	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
title_full_unstemmed	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
title_sort	stat3 serine phosphorylation is required for tlr4 metabolic reprogramming and il-1β expression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

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