Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants

Implantation is an essential issue in orthopedic surgery. Bulk metallic glasses (BMGs), as a kind of novel materials, attract lots of attentions in biological field owing to their comprehensive excellent properties. Here, we show that a Zr61Ti2Cu25Al12 (at. %) BMG (Zr-based BMG) displays the best cy...

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Autores principales:	K. Sun, R. Fu, X.W. Liu, L.M. Xu, G. Wang, S.Y. Chen, Q.J. Zhai, S. Pauly
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Metallic glasses Bio-corrosion Biocompatibility Osteogenesis Angiogenesis Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/56d4902845224b5a9a34834c2e9107e4
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id	oai:doaj.org-article:56d4902845224b5a9a34834c2e9107e4
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spelling	oai:doaj.org-article:56d4902845224b5a9a34834c2e9107e42021-11-04T04:35:32ZOsteogenesis and angiogenesis of a bulk metallic glass for biomedical implants2452-199X10.1016/j.bioactmat.2021.06.018https://doaj.org/article/56d4902845224b5a9a34834c2e9107e42022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003042https://doaj.org/toc/2452-199XImplantation is an essential issue in orthopedic surgery. Bulk metallic glasses (BMGs), as a kind of novel materials, attract lots of attentions in biological field owing to their comprehensive excellent properties. Here, we show that a Zr61Ti2Cu25Al12 (at. %) BMG (Zr-based BMG) displays the best cytocompatibility, pronounced positive effects on cellular migration, and tube formation from in-vitro tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone. The in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation. Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based BMG. Accordingly, the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based BMG. Dynamic gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery, simultaneously, without abnormal ionic accumulation and inflammatory reactions. Considering suitable mechanical properties, we provide a realistic candidate of the Zr61Ti2Cu25Al12 BMG for biomedical applications.K. SunR. FuX.W. LiuL.M. XuG. WangS.Y. ChenQ.J. ZhaiS. PaulyKeAi Communications Co., Ltd.articleMetallic glassesBio-corrosionBiocompatibilityOsteogenesisAngiogenesisMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 253-266 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metallic glasses Bio-corrosion Biocompatibility Osteogenesis Angiogenesis Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Metallic glasses Bio-corrosion Biocompatibility Osteogenesis Angiogenesis Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 K. Sun R. Fu X.W. Liu L.M. Xu G. Wang S.Y. Chen Q.J. Zhai S. Pauly Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
description	Implantation is an essential issue in orthopedic surgery. Bulk metallic glasses (BMGs), as a kind of novel materials, attract lots of attentions in biological field owing to their comprehensive excellent properties. Here, we show that a Zr61Ti2Cu25Al12 (at. %) BMG (Zr-based BMG) displays the best cytocompatibility, pronounced positive effects on cellular migration, and tube formation from in-vitro tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone. The in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation. Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based BMG. Accordingly, the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based BMG. Dynamic gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery, simultaneously, without abnormal ionic accumulation and inflammatory reactions. Considering suitable mechanical properties, we provide a realistic candidate of the Zr61Ti2Cu25Al12 BMG for biomedical applications.
format	article
author	K. Sun R. Fu X.W. Liu L.M. Xu G. Wang S.Y. Chen Q.J. Zhai S. Pauly
author_facet	K. Sun R. Fu X.W. Liu L.M. Xu G. Wang S.Y. Chen Q.J. Zhai S. Pauly
author_sort	K. Sun
title	Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
title_short	Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
title_full	Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
title_fullStr	Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
title_full_unstemmed	Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
title_sort	osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/56d4902845224b5a9a34834c2e9107e4
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Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants

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